Therapeutic Effect Between Quetiapine and Haloperidol on the Treatment of Methamphetamine - Induced Psychosis
试验速览
- 阶段
- 4 期
- 状态
- 已完成
- 入组人数
- 80
- 试验地点
- 1
- 主要终点
- Positive and Negative Syndrome Scale
研究概览
简要总结
The aims of this study are to compare the antipsychotic and adverse events of quetiapine, an atypical antipsychotic drug, to haloperidol, a standard treatment for primary psychotic disorder, in individuals with MAP.
详细描述
Eighty individuals with MAP will be randomly assigned into two treatment groups, i.e. treatment with quetiapine and haloperidol. The quetiapine group will receive quetiapine at least 100 mg per day and the haloperidol group will receive haloperidol at least 2 mg per day orally once a day for four weeks. The doses will be increased every 5 days until no psychotic symptom is observed from the Positive and Negative Syndrome Scale. Common antipsychotic adverse events will be checked and documented daily.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Triple (Participant, Care Provider, Investigator)
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Having a psychotic episode with current use of methamphetamine
- •Positive urine toxicology test for methamphetamine on the first day of hospitalization
排除标准
- •Using other illegal substances
- •Having a history of primary psychotic disorders or using antipsychotic agents
- •Having a chronic medical disease, e.g. essential hypertension, diabetes, epilepsy, stroke
研究组 & 干预措施
Quetiapine
Quetiapine 100 mg per day is taken orally once a day for four weeks. The dose is increased every 5 days until no psychotic symptom is observed.
干预措施: Diazepam (Drug)
Quetiapine
Quetiapine 100 mg per day is taken orally once a day for four weeks. The dose is increased every 5 days until no psychotic symptom is observed.
干预措施: Vitamin B1-6-12 (Dietary Supplement)
Quetiapine
Quetiapine 100 mg per day is taken orally once a day for four weeks. The dose is increased every 5 days until no psychotic symptom is observed.
干预措施: Stugeron (Drug)
Haloperidol
Haloperidol 2 mg per day is taken orally once a day for four weeks. The dose is increased every 5 days until no psychotic symptom is observed.
干预措施: Diazepam (Drug)
Haloperidol
Haloperidol 2 mg per day is taken orally once a day for four weeks. The dose is increased every 5 days until no psychotic symptom is observed.
干预措施: Vitamin B1-6-12 (Dietary Supplement)
Haloperidol
Haloperidol 2 mg per day is taken orally once a day for four weeks. The dose is increased every 5 days until no psychotic symptom is observed.
干预措施: Stugeron (Drug)
结局指标
主要结局
Positive and Negative Syndrome Scale
时间窗: Every two days in Week 2 and 3.
次要结局
- Antipsychotic Adverse Event Form(Every day for three weeks.)
研究者
Rasmon Kalayasiri
Assistant Professor
Chulalongkorn University