The effect of Allopurinol on prevention of contrast-induced nephropathy

Phase 2

• Conditions: Acute renal failure.; Acute renal impairment

• Registration Number: IRCT2014072318389N2
• Lead Sponsor: Qom University of Medical Sciences and Health Services Vice chancellor for research

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 22 February 2018

Recruitment & Eligibility

• Status: Complete
• Sex: All
• Target Recruitment: 140

Inclusion Criteria

Patients, who have at least one of the following risk factors: 1) Heart failure (25%75 years 4) Renal insufficiency (creatinine 1.5mg/dl) 5) Hypotension (SBP<80 mm Hg for 1 hour) 6) GFR<60/mL/min per 1.73 m2 7) Anemia 8) hypertension 9) Pulmonary edema Exclusion criteria: 1- Pregnancy and lactation 2- Allergy to radiographic contrast 3- Have cardiogenic shock and pulmonary edema during study 4- multiple myeloma, pulmonary ventilation and emergency catheterization 5- Serum creatinine levels< 4 mg/dL and preexisting dialysis 6- Exposure to contrast medium 48 h pre- and post-coronary angiography 7- Receive of diuretics, N-acetylcystein, sodium bicarbonate, Theophylline, Dopamine, Mannitol, Fenoldopam, Metformin and NSAID’S during the study 8- Needs to continuous hydration therapy (e.g., sepsis)

Exclusion Criteria

Not provided

Study & Design

• Study Type: interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
ephropathy. Timepoint: Before and 48 h after coronary angiography. Method of measurement: Serum creatinine, blood urea nitrogen (BUN), CRP and uric acid measurement.