Exercise-induced pulmonary hypertension in fibrotic idiopathic interstitial pneumonias. Correlations with cardiopulmonary exercise testing

Recruiting

• Conditions: fibrosing interstitial lung disease; lung fibrosis; 10019280; 10037454

• Registration Number: NL-OMON39384
• Lead Sponsor: Onze Lieve Vrouwe Gasthuis

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 29 April 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: Not specified
• Target Recruitment: 30

Inclusion Criteria

-IIP patients, defined as IPF or fibrotic NSIP will be included in the study. Diagnosis ill be made according to the ATS/ERS guidelines (1, 23).
- Informed consent
- > 18 years of age
- Male and female

Exclusion Criteria

-Occupational or environmental cause for the pulmonary fibrosis.
-Age <= 18 years of age
-Pregnancy
-Patients not able to perform a cycling test

Study & Design

• Study Type: Observational non invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Main study parameters are systolic pulmonary arterial pressure and ventilatory<br /><br>equivalents for CO2 at anaerobic threshold </p><br>

Secondary Outcome Measures

Name	Time	Method
<p>CPET parameters; peak oxygen uptake (peak V*O2), V*O2 at the anaerobic<br /><br>threshold, ventilatory reserve, the ventilatory equivalent for O2 and CO2 (V*E/<br /><br>V*O2 and V*E/V*CO2) at peak exercise, and oxygen-pulse (O2-pulse (V*O2/HR)).<br /><br>Baseline spirometry and diffusion capacity. Biomarkers of (left and right)<br /><br>ventricular strain (NT-proBNP).</p><br>