ACTRN12614000319673
Completed
未知
Evaluation of the cholinergic hypothesis with neurophysiological interventions such as Pupillometry and Mangina-Test in Myasthenia Gravis patients (MG)
Antonia Kaltsatou0 sites66 target enrollmentMarch 25, 2014
Overview
- Phase
- 未知
- Intervention
- Not specified
- Conditions
- Not specified
- Sponsor
- Antonia Kaltsatou
- Enrollment
- 66
- Status
- Completed
- Last Updated
- 6 years ago
Overview
Brief Summary
No summary available.
Investigators
Eligibility Criteria
Inclusion Criteria
- •All patients were diagnosed with MG (mean time from the diagnosis was until the beginning of the study 2\.9\+/\-0\.2 years) using the established and diagnosis criteria. Specifically, their diagnosis was based on one hand on the clinical symptoms (fatigue during the day, etc), and on the other hand, on the laboratory findings (presence of positive antibodies for the AchR, positive response at the repeated stimuli test). Apart from these, MG patients showed an improvement of the muscle strength following the intake of edrophonium chloride and reacted positively to Mestinon. It was a key inclusion criterion that participants previously showed an improvement of the muscle strength following the intake of edrophonium chloride and reacted positively to Mestinon because from this we were sure that the Myasthenia Gravis Diagnosis was correct.
- •All patients were free of any other neurological, ophthalmological, physical or mental disease and their visual acuity, corrected or not, were 20/20\. Moreover, they had symmetrical pupils and no past history of ocular operations or diseases affecting the pupil and were not being treated at that time with anticholinergics, steroids, sympathomimetics, beta\-blockers or other agents affecting the Pupil Light Reflex (PLR). Also, the basic precondition for participation was a mini mental score greater than or equal to 22\. All measurements were performed between 09\.00 and 10\.00 hours after the participants had had a full eight\-hour sleep.
Exclusion Criteria
- •If MG patients do not show an improvement of the muscle strength following the intake of edrophonium chloride and reacted positively to Mestinon.
Outcomes
Primary Outcomes
Not specified
Similar Trials
Completed
Not Applicable
A cross sectional study of subtypes of cholinergic uriticaria and bronchial hyperresponsivenessCholinergic urticariaJPRN-UMIN000025669Kobe University33
Completed
Not Applicable
Evaluation of the usefulness of anti-cholinergic and B(Beta)3 agonist in patients with OAB.Overactive bladderJPRN-UMIN000008863Clinical Research Support Center Kyushu400
Active, not recruiting
Phase 1
In vivo involvement of the cholinergic and dopaminergic systems in the pathophysiology of apathy.EUCTR2018-003286-34-FRCHU de Bordeaux30
Completed
Not Applicable
Imaging the neural correlates of rehabilitation in Wernicke's aphasiaPost-stroke aphasiaSigns and SymptomsSymptoms and signs involving speech and voiceISRCTN68939136Joint UCLH and UCL Biomedical Research Unit (UK)30
Active, not recruiting
Phase 1
Imaging the neural correlates of cholinergic and behaviour driven rehabilitation in patients with Wernicke’s aphasia: a double-blinded, cross-over, randomised controlled trial. - Imaging the neural correlates of rehabilitation in Wernicke’s aphasia.Wernicke's aphasia caused by a strokeEUCTR2005-004215-30-GBJoint Sponsorship: University College London (UCL) & University College London Hospitals (UCLH)60