Breast MRI in Evaluation of Pathologic Response in Patients With Breast Cancer With Neoadjuvent Chemotherapy

Not yet recruiting

• Conditions: Role of MRI in Evaluation of Breast Cancer

• Registration Number: NCT05301790
• Lead Sponsor: Assiut University

Brief Summary

evaluation of pathological response in breast mass by use of breast MRI in patients receiving neoadjuvent chemotherapy via comparison with pathological results

Detailed Description

evaluation of pathological response in locally advanced breast masses by use of breast MRI in patients receiving neoadjuvent chemotherapy via comparison with pathological results

Study Timeline

• Status Verified: 2022-03
• Study First Submitted: 2022-03-20
• Study First Submitted QC: 2022-03-20
• Last Update Submitted: 2022-03-20
• Study First Posted: 2022-03-31
• Last Update Posted: 2022-03-31
• Study Start: 2022-05
• Primary Completion: 2024-06
• Study Completion: 2024-12

Recruitment & Eligibility

• Status: NOT_YET_RECRUITING
• Sex: Female
• Target Recruitment: 45

Inclusion Criteria

• all women referred to the radiology department for breast MRI examination either for screening, evaluation of suspicious lesions onsono-mammography \

  • Patients with locally advanced breast cancer
  • Patients with early stage breast cancer and chemo-responsive tumour markers (i.e. triple negative, Her2+), who will benefit from downsizing for breast conserving surgery (BCS)
  • Absolute or Relative contraindications to surgery (advanced age/multiple medical comorbidities) in the setting of estrogen receptor positive tumours (for consideration of neoadjuvant endocrine therapy)3
  • Patients must be elder than 18 years old.

• patients with accepted renal function

Exclusion Criteria

• Patients with metastatic breast cancer.
• Patient with breast mass more than 5 cm .
• Patients with fungating breast mass .
• Patients with stage IV [tumor spread to chest wall and to skin ].
• pregnant women especially in 1th trimester.
• Patient with presence of any paramagnetic substance as pacemakers.
• severely ill patients .
• patients with claustrophobia.
• arrhythmic patients

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
comparison of MRI findings with pathologic results	baseline	added value of breast MRI in evaluation of pathologic response in patients with locally advanced breast cancer who undergo neoadjvent chemotherapy