Prevention After Stroke - a Nurse-led Physician-supervised Model

Not Applicable

Completed

• Conditions: Stroke
• Interventions: Behavioral: Intervention

• Registration Number: NCT03782857
• Lead Sponsor: Nete Hornnes

Brief Summary

The study evaluates the effect of early follow up in a preventive clinic with stepwise treatment of high blood pressure and lowering blood cholesterol. Half the participants were randomized to the preventive clinic group and the other half to control group with the usual treatment: one visit to the outpatient clinic three months after discharge with a diagnosis of stroke or transient ischemic attack (TIA)

Detailed Description

Hypertension is the most important modifiable risk factor for recurrent stroke. Several studies have shown that less than 40% of stroke survivors are treated to target one year after stroke The investigator performed a feasibility study to test a model of treating this important risk factor in a hospital setting The investigator used a stepwise escalation of treatment of both blood pressure and blood cholesterol to individual targets according to patients' diagnosis of stroke, comorbidity and age

Study Timeline

• Study Start: 2012-06-26
• Primary Completion: 2013-12-17
• Study Completion: 2013-12-17
• Status Verified: 2018-12
• Study First Submitted: 2018-12-19
• Study First Submitted QC: 2018-12-19
• Study First Posted: 2018-12-20
• Last Update Submitted: 2018-12-20
• Last Update Posted: 2018-12-21

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 78

Inclusion Criteria

Patients diagnosed with a stroke during stay in the stroke unit of Herlev Hospital

Exclusion Criteria

Severe stroke giving a modified Rankin Scale score >4, severe cognitive deficits or dementia, discharge to a nursing home

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Intervention group	Intervention	Initiation/stepwise escalation of antihypertensive medication in case of blood pressure above individual target Initiation/stepwise escalation of cholesterol lowering medication in case of LDL-cholesterol above individual target Advice on healthy lifestyle and life long adherence to preventive medication

Primary Outcome Measures

Name	Time	Method
Blood pressure treated to target	At follow up 10 months after inclusion in the study	The investigator used individual targets of blood pressure: In case of hemorrhagic stroke: BP\<130/80 mm Hg, in case of ischemic heart disease: BP target according to stroke diagnosis, but no lower than 130/80 mm Hg, in case of diabetes or chronic kidney disease: BP\<130/80 mm Hg, age\>80 years: \<150/90 mm Hg, others: \<140/90 mm Hg

Secondary Outcome Measures

Name	Time	Method
Reduction in blood pressure	At follow up 10 months after inclusion in the study	Difference between blood pressure at inclusion in the study and blood pressure measured at final follow up