Factors Affecting Success of IUI in Women With Unexplained Infertility
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 100
- 主要终点
- chemical pregnancy rate
研究概览
简要总结
Superovulation will be conducted with 100 mg of oral clomiphene citrate (Clomifene; Young Poong Pharmaceutical, Incheon, Korea) for 5 days starting on day 3 of the menstrual cycle, followed by daily injection of 150 IU of human menopausal gonadotropin (hMG;Menogon; FerringPharamceutical Co, Germany). When more than 2 dominant follicles reached a diameter of 17 mm or the urinary specimen showed positive results for luteinizing hormone (LH) surge, 5000 IU of hCG (Pregnyl; Organon, Oss, the Netherlands) was injected intramuscularly.
详细描述
Superovulation will conducted with 100 mg of oral clomiphene citrate (Clomifene; Young Poong Pharmaceutical, Incheon, Korea) for 5 days starting on day 3 of the menstrual cycle, followed by daily injection of 150 IU of human menopausal gonadotropin (hMG;Menogon; FerringPharamceutical Co, Germany). When more than 2 dominant follicles reached a diameter of 17 mm or the urinary specimen showed positive results for luteinizing hormone (LH) surge, 5000 IU of hCG (Pregnyl; Organon, Oss, the Netherlands) was injected intramuscularly. Successful pregnancy after IUI was confirmed by ultrasound as one or more visible gestational sacs in the uterine cavity.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Diagnostic
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 40 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •These patients had at least 1 tube patent
- •there were no significant intrauterine or pelvic abnormalities demonstrated on pelvic-abdominal ultrasonography, hysteroscopy, and/or laparoscopy
- •serum follicular stimulating hormone (FSH) level of12 mIU/mL or less
排除标准
- •A woman's age of more than 40 years,
- •ovarian cyst detected in the ultrasound examination
- •uterine lesions such as submucosal leiomyoma, and a previous diagnosis of moderate to severe pelvic endometriosis.
- •women with body mass index > 35 kg/m2,
- •PCOS/anovulatory patients
- •signs of hyperandrogenemia
研究组 & 干预措施
Pregnant
women with positive serum beta HCG done 14 days after Intrauterine insemenation
干预措施: Intrauterine insemenation (Device)
Nonpregnant
women with negative serum beta HCG done 14 days after Intrauterine insemenation
干预措施: Intrauterine insemenation (Device)
结局指标
主要结局
chemical pregnancy rate
时间窗: 14 days after IUI
次要结局
未报告次要终点
研究者
Ahmed Maged
Assistant professor
Cairo University