Comparison of Clinical Outcome Among Vaccinated and Unvaccinated Coronavirus Disease Patients in Critical Care Unit.

• Conditions: Critical Illness; Coronavirus Infections
• Interventions: Drug: Vaccine

• Registration Number: NCT05331742
• Lead Sponsor: Civil Service Hospital of Nepal

Brief Summary

Corona virus disease has been a pandemic since its beginning. The problem has scaled to break health care system of multiple countries. One of the prime strategy of preventing this disease has been large mass scale vaccination campaign ongoing worldwide. No vaccine has been proven to 100 percent effective in preventing the infection with coronavirus disease so far. The investigators are conducting a study comparing outcome among vaccinated and unvaccinated population admitted to critical care unit of civil services hospital, Kathmandu , Nepal .

Detailed Description

Coronavirus disease has been a pandemic since its beginning. The problem has scaled up and health care system of multiple countries have reached to a breaking point . One of the prime strategy of preventing this disease has been large mass scale vaccination campaign ongoing worldwide. No vaccine has been proven to 100 percent effective in preventing the infection with coronavirus disease so far. The investigators are conducting a study comparing difference in outcome with regard to mortality and length of critical care unit stay among vaccinated and unvaccinated population admitted to critical care unit of civil services hospital , Kathmandu , Nepal.

Since different groups of population received different vaccine according to age profession and other factors investigators are trying to study the effectiveness of vaccine with regards to type of vaccine.

Study Timeline

• Status Verified: 2022-04
• Study First Submitted: 2022-04-08
• Study First Submitted QC: 2022-04-09
• Last Update Submitted: 2022-04-09
• Study Start: 2022-04-15
• Primary Completion: 2022-04-15
• Study First Posted: 2022-04-18
• Last Update Posted: 2022-04-18
• Study Completion: 2022-06-01

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 200

Inclusion Criteria

patients proven to have covid 19 infection patients more than 18 years of age patients admitted to critical care unit

Exclusion Criteria

• patient below 18 years of age patients who do not have covid 19 infection

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
vaccinated	Vaccine	patient between age 18 and above who have received a complete dose of coronavirus disease vaccine patient who has been admitted to critical care unit due to corona virus disease infection

Primary Outcome Measures

Name	Time	Method
Mortality	within 12 weeks from the date of critical care unit admission	the primary outcome to be measured will be difference in mortality among two groups (vaccinated and unvaccinated) of coronavirus infected patients admitted in critical care unit
length of icu stay	with 12 weeks from the date of critical care unit admission	difference in length of stay between vaccinated and unvaccinated population admitted to critical care unit after being infected with coronavirus disease

Secondary Outcome Measures

Name	Time	Method
difference in mortality due to associated co-morbidity	within 24 weeks form the date of critical care unit admission	difference in mortality due to associated co-morbidity will be compared among both the group (vaccinated and unvaccinated)