The Impact of Chokeberry Bioproducts on Metabolic Parameters and Antioxidant Potential

Not Applicable

Completed

• Conditions: Diet, Healthy; Hypercholesterolemia; Hypertension; Diabetes Mellitus; Obesity
• Interventions: Other: Dietary intervention with chokeberry juices; Other: Dietary intervention with chokeberry juices and fibers

• Registration Number: NCT06435130
• Lead Sponsor: Medical University of Bialystok

Brief Summary

Chokeberry can be used both in the prevention and treatment of various metabolic disorders due to its high antioxidant properties. The study assessed for the first time the synergistic effect of chokeberry juice and chokeberry fiber on selected metabolic and anthropometric parameters. 102 people (67 women and 35 men) took part in the intervention study. After 8 weeks of intervention with chokeberry juice and another 4 weeks of intervention with chokeberry juice and fiber, a change in waist circumference, blood pressure, glucose, glycated hemoglobin, LDL cholesterol, aspartate transaminase (AST) and the level of antioxidant potential was observed.

Detailed Description

Not available

Study Timeline

• Study Start: 2022-05-01
• Primary Completion: 2022-08-30
• Study Completion: 2022-08-30
• Status Verified: 2024-05
• Study First Submitted: 2024-05-20
• Study First Submitted QC: 2024-05-23
• Last Update Submitted: 2024-05-23
• Study First Posted: 2024-05-30
• Last Update Posted: 2024-05-30

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 102

Inclusion Criteria

• age 30-65 years,
• low or moderate physical activity.

Exclusion Criteria

• age <30 and >65 years,
• high physical activity,
• obesity (class II),
• diabetes (all types),
• gastric ulcer,
• acute or chronic gastritis,
• intestinal diseases, including inflammatory bowel diseases and functional intestinal disorders,
• taking hypoglycemic, lipid-lowering, immunosuppressive, anticoagulant and antihypertensive drugs, use of steroid therapy,
• high physical activity,
• pregnancy,
• breastfeeding.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
Dietary intervention with chokeberry juice and fibre	Dietary intervention with chokeberry juices	Study participants consumed 100 mL of chokeberry juice daily for 8 weeks. After 8 weeks, participants consumed 100 ml of chokeberry juice and 10 g of chokeberry fiber daily for 4 weeks.
Dietary intervention with chokeberry juice and fibre	Dietary intervention with chokeberry juices and fibers	Study participants consumed 100 mL of chokeberry juice daily for 8 weeks. After 8 weeks, participants consumed 100 ml of chokeberry juice and 10 g of chokeberry fiber daily for 4 weeks.

Primary Outcome Measures

Name	Time	Method
Change in glycated hemoglobin	12 weeks	After 8 weeks of using chokeberry juice-100 mL daily and another 4 weeks of using chokeberry juice - 100 mL daily and chokeberry fiber - 10 g daily, a change in glycated hemoglobin was observed.
Change in antioxidant potential of serum	12 weeks	After 8 weeks of using chokeberry juice-100 mL daily and another 4 weeks of using chokeberry juice - 100 mL daily and chokeberry fiber - 10 g daily, a change in antioxidant potential of serum was observed.
Change in waist circumference	12 weeks	After 8 weeks of using chokeberry juice-100 mL daily and another 4 weeks of using chokeberry juice - 100 mL daily and chokeberry fiber - 10 g daily, a change in waist circumference was observed.
Change in glucose level	12 weeks	After 8 weeks of using chokeberry juice-100 mL daily and another 4 weeks of using chokeberry juice - 100 mL daily and chokeberry fiber - 10 g daily, a change in glucose level was observed.
Change in aspartate transaminase (AST) level	12 weeks	After 8 weeks of using chokeberry juice-100 mL daily and another 4 weeks of using chokeberry juice - 100 mL daily and chokeberry fiber - 10 g daily, a change in aspartate transaminase (AST) level was observed.
Change in blood pressure	12 weeks	After 8 weeks of using chokeberry juice-100 mL daily and another 4 weeks of using chokeberry juice - 100 mL daily and chokeberry fiber - 10 g daily, a change in systolic and diastolic blood pressure was observed.
Change in LDL-cholesterol	12 weeks	After 8 weeks of using chokeberry juice-100 mL daily and another 4 weeks of using chokeberry juice - 100 mL daily and chokeberry fiber - 10 g daily, a change in LDL-cholesterol level was observed.

Trial Locations

Locations (1)

Medical University of Bialystok; 🇵🇱 Białystok, Poland