Intensive versus conventional insulin therapy for inpatient medical patients [Insulinoterapia intensificada versus terapia habitual en pacientes hospitalizados por patología médica]
- Conditions
- HyperglycaemiaSigns and SymptomsElevated blood glucose level
- Registration Number
- ISRCTN55845280
- Lead Sponsor
- ational Fund of Investigation and Development in Health (Fondo nacional de investigación y desarrollo en salud [FONIS]) (Chile)
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- All
- Target Recruitment
- 250
Adult inpatients (aged greater than 18 years, men and women) with an acute medical or surgical condition, and any of the following criteria:
1. In subjects known to have diabetes: Capillary blood glucose level over 180 mg/dl, in consecutive measurements separated by 2 hours, or just one measurement if insulin was administered after the first
2. In subjects without previous diagnosis of diabetes: Capillary blood glucose level over 200 mg/dl in consecutive measurements separated by 2 hours, or just one measurement if insulin was administered after the first
1. Pregnancy
2. Acute complications of diabetes
3. Terminal illness (expected survival of less than a month)
4. Elective hospitalisation
5. Hospitalisation stay predicted to last less than 72 hours
6. Haemodyalisis initiated during hospitalisation
7. Peritoneal dialysis
8. Corticosteroids (prednisone) dose over 30 mg/day
9. Parenteral nutrition
10. Inability to receive carbohydrates by mouth for more than 8 hours
11. Patients with an unresolved surgical condition
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method umber of measurements of blood glucose levels between 70 and 130 mg/dl. All measurements will be recorded at day 7 and at the moment of discharge.
- Secondary Outcome Measures
Name Time Method 1. Mean blood glucose level<br>2. Length of hospitalisation<br>3. Healthcare-associated infections<br>4. Number of measurements of blood glucose levels below 70 mg/dl<br>5. Time to achieve good glycaemic control (two or more measurements between 70 and 130 mg%)<br><br>All measurements will be recorded at day 7 and at the moment of discharge.