Comparative study of the effect of pulsatile flow vresus non pulsatile flow on the antioxidant markers pre cardiopulmonary bypass in patients undergoing complex cardiac surgery
Phase 3
Recruiting
- Conditions
- Patients undergoing complex cardiac surgery.Mechanical complication of coronary artery bypass graft and biological heart valve graftT82.2
- Registration Number
- IRCT20240316061314N1
- Lead Sponsor
- Rajaee heart center
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- 44
Inclusion Criteria
Patients conscious satisfaction
Age range of 18 to 75
Patients undergoing elective complex surgery on CPB
Patients with 30% = Ejection fraction
Having no history of heart surgery
Having no liver dysfunction AST>140 unite / L and ALT>40 unite / L and no lung dysfunction like FEV1>65%
CR<2
HB>10
Having no active inflammation since 1 month ago
Not using antioxidant and anti inflammatory drugs since 1 month ago
Exclusion Criteria
Aortic cross clamp time <20 min
Pulse pressure <20 mmhg
Redo surgeries
Emergency surgeries
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Examination of malondialdehyde at specified times. Timepoint: Preoperatively, immediately after bypass, 24 hours later in the intensive care unit. Method of measurement: Blood test.;Total antioxidant capacity. Timepoint: Preoperatively, immediately after bypass, 24 hours later in the intensive care unit. Method of measurement: Blood test.;Lactat. Timepoint: Preoperatively, immediately after bypass, 24 hours later in the intensive care unit. Method of measurement: Blood test.
- Secondary Outcome Measures
Name Time Method ICU stay. Timepoint: Post operative. Method of measurement: patients file.;Ventilation time. Timepoint: Post operative. Method of measurement: Patients file.;Reducing mortality and morbidity. Timepoint: Post operative. Method of measurement: patients file.