Comparative study of the effect of pulsatile flow vresus non pulsatile flow on the antioxidant markers pre cardiopulmonary bypass in patients undergoing complex cardiac surgery
Phase 3
Recruiting
- Conditions
- Patients undergoing complex cardiac surgery.Mechanical complication of coronary artery bypass graft and biological heart valve graftT82.2
- Registration Number
- IRCT20240316061314N1
- Lead Sponsor
- Rajaee heart center
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- 44
Inclusion Criteria
Patients conscious satisfaction
Age range of 18 to 75
Patients undergoing elective complex surgery on CPB
Patients with 30% = Ejection fraction
Having no history of heart surgery
Having no liver dysfunction AST>140 unite / L and ALT>40 unite / L and no lung dysfunction like FEV1>65%
CR<2
HB>10
Having no active inflammation since 1 month ago
Not using antioxidant and anti inflammatory drugs since 1 month ago
Exclusion Criteria
Aortic cross clamp time <20 min
Pulse pressure <20 mmhg
Redo surgeries
Emergency surgeries
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method
- Secondary Outcome Measures
Name Time Method
Related Research Topics
Explore scientific publications, clinical data analysis, treatment approaches, and expert-compiled information related to the mechanisms and outcomes of this trial. Click any topic for comprehensive research insights.
What molecular mechanisms underlie pulsatile flow's impact on antioxidant markers in complex cardiac surgery patients?
How does pulsatile flow compare to non-pulsatile flow in preserving antioxidant capacity during cardiopulmonary bypass in complex cardiac procedures?
Which antioxidant biomarkers are most predictive of outcomes in patients with mechanical complications of coronary artery bypass graft and biological heart valve graft (T82.2) undergoing pulsatile flow?
What adverse events are associated with pulsatile flow cardiopulmonary bypass in complex cardiac surgery and how are they managed?
Are there combination therapies or alternative perfusion strategies that enhance antioxidant protection compared to pulsatile flow in complex cardiac surgery?