NCT00337766已完成4 期
Efficacy of Desmopressin (1-deamin0-8-D-arginine-vasopressin) in Reducing Active Microvascular Bleeding After Cardiac Surgery
适应症
干预措施
相关药物
试验速览
- 阶段
- 4 期
- 状态
- 已完成
- 试验地点
- 4
- 主要终点
- Reduce transfusions
研究概览
简要总结
Patients undergoing cardiac surgery could develop excessive perioperative bleeding requiring transfusions of blood products.
Desmopressin (DDAVP), already used for patients with von Willebrand syndrome, could reduce bleeding and transfusion requirements in these patients when administered ev (0.3 mg/kg) in 20-30 minutes postoperatively.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 100 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •undergoing cardiac surgery
- •excessive bleeding
排除标准
- •age<18 y
- •not signing written consent
研究组 & 干预措施
Desmopressin (DDAVP)
Active Comparator
干预措施: Desmopressin (DDAVP) (Drug)
Placebo
Placebo Comparator
干预措施: Placebo (Drug)
结局指标
主要结局
Reduce transfusions
次要结局
- Reduced bleeding
- Reduce time on mechanical ventilation
- Reduced ICU and Hospital stay
- Reduced mortality
研究者
研究点 (4)
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