Remote Ischemic Conditioning and Atrial Fibrillation After Coronary Artery Bypass Grafting (CABG)
Not Applicable
Terminated
- Conditions
- Atrial Fibrillation
- Registration Number
- NCT01107184
- Brief Summary
Recent studies indicate that remote ischemic conditioning can protect the heart and other organs during cardiac surgery. The investigators aim to investigate whether such a stimulus can reduce the incidence of atrial fibrillation or other complications following coronary artery bypass surgery.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- TERMINATED
- Sex
- All
- Target Recruitment
- 191
Inclusion Criteria
- Elective on-pump CABG surgery
- Informed consent
Exclusion Criteria
- Prior cardiac surgery (Re-operations)
- Prior atrial fibrillation
- Use of class 1 or 3 anti arrhythmic medication or digoxin Use of intermittent aortic cross clamping during surgery
- Age <18 years
- Left ventricular ejection fraction ≤30%
- Serious pulmonary disease (resting pO2 <90% at room air)
- Renal failure (clearance <30 ml/min as calculated using the Modification of Diet in Renal Disease formula)
- Liver failure
- Use of the sulfonylurea derivative glibenclamide (this drug is known to block any preconditioning stimulus
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Primary Outcome Measures
Name Time Method Post-operative atrial fibrillation 72 hours
- Secondary Outcome Measures
Name Time Method Major cardiovascular and cerebrovascular events 3 months, 6 months, 1 year Major adverse events, i.e. death, acute coronary syndrome, stroke.
Length of stay 1 week on avarage Duration of hospitalization and stay on the ICU
Trial Locations
- Locations (1)
Academic Medical Center, University of Amsterdam
🇳🇱Amsterdam, Netherlands
Academic Medical Center, University of Amsterdam🇳🇱Amsterdam, Netherlands