Applicability of a novel anti-lipoarabinomannan monoclonal antibody to detect Mycobacterium tuberculosis in formalin-fixed paraffin-embedded tissue
Not Applicable
Active, not recruiting
- Conditions
- TuberculosislipoarabinomannanimmunohistochemistryAFBPCRtuberculosis
- Registration Number
- TCTR20190906001
- Lead Sponsor
- Ratchadapiseksompotch Fund, Faculty of Medicine
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Active, not recruiting
- Sex
- All
- Target Recruitment
- 120
Inclusion Criteria
Cases with available PCR result from July 2017- December 2018
Exclusion Criteria
No paraffin block available in the department
Insufficient tissue in the paraffin block
No clinical information provided
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Diagnostic ability of anti-lipoarabinomannan monoclonal antibody compared with culture immediately after complete staining evaluation Sensitivity, specificity, PPV, NPV
- Secondary Outcome Measures
Name Time Method Correlation between anti-lipoarabinomannan monoclonal antibody and histomorphology after complete staining evaluation ROC curve,Correlation between anti-lipoarabinomannan monoclonal antibody and immunocompromised status after complete staining evaluation ROC curve,Cut-off number of positive dots which is correlated with positive culture result after complete staining evaluation ROC curve