COX-2 Regulation of Renal Sodium Handling in Blood Pressure Maintenance
试验速览
- 阶段
- 4 期
- 状态
- 已完成
- 入组人数
- 12
- 试验地点
- 1
- 主要终点
- Mean Arterial Pressure
研究概览
简要总结
The purpose of this study is to determine if the drug Celebrex changes the way the kidney gets rid of salt and maintains blood pressure.
详细描述
There have been many studies done with analgesics such as acetaminophen and non-steroidal anti-inflammatory drugs; however it is not understood how blood pressure changes while using Celebrex. The study hypothesis is that Celebrex will increase salt sensitivity of blood pressure.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Basic Science
- 盲法
- Double (Participant, Investigator)
入排标准
- 年龄范围
- 22 Years 至 50 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •healthy men and women
排除标准
- •history of heart disease
- •have had heart surgery
- •high blood pressure
- •any other disease such as kidney or neurological diseases
- •taking medications such as aspirin or medicines for your heart or blood pressure
- •have asthma or are allergic to sulfa drugs
- •body mass index greater than 30
- •use tobacco
- •women using oral contraceptives or hormone replacement therapy
研究组 & 干预措施
Celebrex; Low sodium
Subject completes a normal sodium diet (3 days), a low salt diet (7 days), followed by a high salt diet (7 days) while taking a celebrex pill (100 mg twice a day for 17 day trial), randomized for trial order (drug versus placebo) and sodium diet order (low versus high sodium).
干预措施: celecoxib (Celebrex) (Drug)
Celebrex, High Sodium
Subject completes a normal sodium diet (3 days), a high salt diet (7 days), followed by a low salt diet (7 days) while taking a celebrex pill (100 mg twice a day for 17 day trial), randomized for trial order (drug versus placebo) and sodium diet order (low versus high sodium).
干预措施: celecoxib (Celebrex) (Drug)
Placebo, Low Sodium
Subject completes a normal sodium diet (3 days), a low salt diet (7 days), followed by a high salt diet (7 days) while taking a placebo pill (twice a day for 17 day trial), randomized for trial order (drug versus placebo) and sodium diet order (low versus high sodium).
干预措施: Placebo (Other)
Placebo, High Sodium
Subject completes a normal sodium diet (3 days), a high salt diet (7 days), followed by a low salt diet (7 days) while taking a placebo pill (twice a day for 17 day trial), randomized for trial order (drug versus placebo) and sodium diet order (low versus high sodium).
干预措施: Placebo (Other)
结局指标
主要结局
Mean Arterial Pressure
时间窗: 24 hours
Blood pressure was measured on the last day of each 7 day sodium diet for 24 hours using an ambulatory blood pressure monitor
次要结局
- Urinary Sodium Excretion(24 hour)
研究者
William Farquhar
Associate Professor and Department Chair, KAAP
University of Delaware