Skeletal complications of prophylactic ciprofloxacin in the treatment of pediatric A
- Conditions
- Acute lymphoblastic leukemia1004323710024324
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 142
Patients:
- age at least ><=8 years old at enrolment in this study
- Patients treated for ALL according to DCOG ALL-10 or ALL-11 protocol
- Patients who received ciprofloxacin as antimicrobial prophylaxis as defined
in the DCOG ALL-10 or ALL-11 protocol, Healthy control group:
- Age *8 years at time of enrolment in this study
- No history of cartilage or bone problems
- Long term ciprofloxacin naive
Patients:
- Patients currently under treatment with ciprofloxacin
- Patients needing general anesthesia to undergo MRI
- Children with Down syndrome or other underlying syndromes
- Patients unable to undergo MRI due to claustrophobia
- Patients with underlying skeletal disorders, including prior fractures of the
knees
- Patients with (juvenile rheumatoid) arthritis
- Patients with metallic implants and foreign bodies in and around the knee
joint (although they may be MRI compatible; image artefacts)
- Contraindications for MRI (e.g. pacemaker), Control group:
- Needing general anesthesia to undergo MRI
- Children with Down syndrome or other underlying syndromes
- Children unable to undergo MRI due to claustrophobia
- Children with underlying skeletal disorders, including prior fractures of the
knees
- Children with (juvenile rheumatoid) arthritis
- Children with metallic implants and foreign bodies in and around the knee
joint (although they may be MRI compatible; image artefacts)
- Contraindications for MRI (e.g. pacemaker)
Study & Design
- Study Type
- Observational invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method
- Secondary Outcome Measures
Name Time Method