NL-OMON21327Not yet recruitingNot Applicable
Cardiovascular Magnetic resonance imaging and Echocardiography in Rheumatoid Arthritis - Patterns of cardiovascular dysfunction in patients with rheumatoid arthritis.
Medisch Spectrum Twente, Enschede, The NetherlandsDepartment of Cardiology and Department of Rheumatology0 sites80 target enrollmentStarted: TBDLast updated:
Conditions
Trial Snapshot
- Phase
- Not Applicable
- Status
- Not yet recruiting
- Sponsor
- Enrollment
- 80
Study Overview
Brief Summary
/A
Study Design
- Study Type
- Observational
Eligibility Criteria
Inclusion Criteria
- •Participants in this study will be selected from a large database of RA patients at the rheumatology department. Three groups of patients with rheumafactor positive and anti-CCP positive rheumatoid arthritis will be selected. The first group consists of 30 patients with new onset rheumatoid arthritis (early RA group, < 1 year disease duration). The second group consists of 20 patients with intermediate duration of rheumatoid arthritis (intermediate RA, 5-10 years disease duration, erosive disease, expert based stable low disease activity > 6 months). The third group consists of 30 patients with longstanding rheumatoid arthritis (longstanding RA, > 15 years disease duration, erosive disease, expert based stable low disease activity > 6 months). The age of the study population is 18-75 year
Exclusion Criteria
- •previous CV disease, current smoking, age < 18 or > 75 years, pregnancy, history of kidney dysfunction (GFR < 60 ml/min), hypercholesterolemia/dyslipidemia (total cholesterol > 6.5 mmol/l), history of hypertension (systolic pressure > 140 mmHg, diastolic pressure > 90 mmHg) or use of antihypertensive medication, history of diabetes mellitus (fasting glucose level > 7.0 mmol/l), body mass index > 30 kg/m2, claustrophobia or other exclusion criteria for MRI such as implanted metal materials.
Investigators
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