Cardiovascular Magnetic resonance imaging and Echocardiography in Rheumatoid Arthritis - Patterns of cardiovascular dysfunction in patients with rheumatoid arthritis.

Medisch Spectrum Twente, Enschede, The NetherlandsDepartment of Cardiology and Department of Rheumatology0 sites80 target enrollmentTBD

Overview

Phase: Not Applicable
Intervention: Not specified
Conditions: - cardiovascular disease - rheumatoid arthritis - cardiac magnetic resonance imaging - echocardiography - cardiovasculaire ziekte - reumatoide artritis - cardiale MRI - echocardiografie
Sponsor: Medisch Spectrum Twente, Enschede, The NetherlandsDepartment of Cardiology and Department of Rheumatology
Enrollment: 80
Status: Not yet recruiting
Last Updated: 2 years ago

Registry

who.int

Start Date

TBD

End Date

TBD

Last Updated

2 years ago

Study Type

Observational non invasive

Sponsor

Medisch Spectrum Twente, Enschede, The NetherlandsDepartment of Cardiology and Department of Rheumatology

•Participants in this study will be selected from a large database of RA patients at the rheumatology department. Three groups of patients with rheumafactor positive and anti\-CCP positive rheumatoid arthritis will be selected. The first group consists of 30 patients with new onset rheumatoid arthritis (early RA group, \< 1 year disease duration). The second group consists of 20 patients with intermediate duration of rheumatoid arthritis (intermediate RA, 5\-10 years disease duration, erosive disease, expert based stable low disease activity \> 6 months). The third group consists of 30 patients with longstanding rheumatoid arthritis (longstanding RA, \> 15 years disease duration, erosive disease, expert based stable low disease activity \> 6 months). The age of the study population is 18\-75 year

•previous CV disease, current smoking, age \< 18 or \> 75 years, pregnancy, history of kidney dysfunction (GFR \< 60 ml/min), hypercholesterolemia/dyslipidemia (total cholesterol \> 6\.5 mmol/l), history of hypertension (systolic pressure \> 140 mmHg, diastolic pressure \> 90 mmHg) or use of antihypertensive medication, history of diabetes mellitus (fasting glucose level \> 7\.0 mmol/l), body mass index \> 30 kg/m2, claustrophobia or other exclusion criteria for MRI such as implanted metal materials.