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临床试验/NCT03744988
NCT03744988Unknown不适用

Serum Androgen Levels as a Marker for the Severity of Preeclampsia

Ain Shams University2 个研究点 分布在 1 个国家目标入组 75 人开始时间: 2017年10月1日最近更新:
适应症

试验速览

阶段
不适用
入组人数
75
试验地点
2
主要终点
serum androgen levels as a marker for the severity of preeclampsia

研究概览

简要总结

this study will be conducted to confirm the hypothesis of the previous studies and to list the high androgen levels as a precipitating factor for preeclampsia

详细描述

hypertensive disorders are one of the most important complications during pregnancy, which in combination with hemorrhage and infections make a dangerous triad, making them the major cause of maternal morbidity and mortality in 3.7-5% of all pregnancies.

Hypertensive disorders during pregnancy are classified into 4 categories, as recommended by the National High Blood Pressure Education Program Working Group on High Blood Pressure in Pregnancy:

  • Chronic hypertension
  • Preeclampsia-eclampsia
  • Preeclampsia superimposed on chronic hypertension
  • Gestational hypertension (transient hypertension of pregnancy or chronic hypertension identified in the latter half of pregnancy). This terminology is preferred over the older but widely used term "pregnancy-induced hypertension" (PIH) because it is more precise .

In 2008, the Society of Obstetricians and Gynecologists of Canada (SOGC) released revised guidelines that simplified the classification of hypertension in pregnancy into 2 categories, preexisting or gestational, with the option to add "with preeclampsia" to either category if additional maternal or fetal symptoms, signs, or test results support this .

Chronic hypertension is defined as blood pressure exceeding 140/90 mm Hg before pregnancy or before 20 weeks' gestation. When hypertension is first identified during a woman's pregnancy and she is at less than 20 weeks' gestation, blood pressure elevations usually represent chronic hypertension.

研究设计

研究类型
Observational
观察模型
Cohort
时间视角
Prospective

入排标准

年龄范围
20 Years 至 35 Years(Adult)
性别
Female
接受健康志愿者

入选标准

  • Pregnant women (primigravidas).
  • Age between 20 and 35 years old.
  • Live fetus.

排除标准

  • Women younger than 20 years old and older than 35 years old
  • Intrauterine fetal death.
  • History of pre-gestational hypertension.
  • History of hormonal disorders (thyroid gland disorders and hyperprolactinemia).
  • Polycystic ovary syndrome.
  • Signs or symptoms of hyper-androgenism (hirsutism, acne, oily skin, etc.).
  • Diabetes mellitus.
  • Drug use except ordinary supplementation (iron, folic acid).

结局指标

主要结局

serum androgen levels as a marker for the severity of preeclampsia

时间窗: 1 week

assess if serum androgen levels could be used as a marker for the severity of preclampsia

次要结局

未报告次要终点

研究者

申办方类型
Other
责任方
Principal Investigator
主要研究者

Joseph Adel Ibrahiem Johny

Principal Investigator

Ain Shams University

研究点 (2)

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