Serum Androgen Levels as a Marker for the Severity of Preeclampsia
试验速览
- 阶段
- 不适用
- 入组人数
- 75
- 试验地点
- 2
- 主要终点
- serum androgen levels as a marker for the severity of preeclampsia
研究概览
简要总结
this study will be conducted to confirm the hypothesis of the previous studies and to list the high androgen levels as a precipitating factor for preeclampsia
详细描述
hypertensive disorders are one of the most important complications during pregnancy, which in combination with hemorrhage and infections make a dangerous triad, making them the major cause of maternal morbidity and mortality in 3.7-5% of all pregnancies.
Hypertensive disorders during pregnancy are classified into 4 categories, as recommended by the National High Blood Pressure Education Program Working Group on High Blood Pressure in Pregnancy:
- Chronic hypertension
- Preeclampsia-eclampsia
- Preeclampsia superimposed on chronic hypertension
- Gestational hypertension (transient hypertension of pregnancy or chronic hypertension identified in the latter half of pregnancy). This terminology is preferred over the older but widely used term "pregnancy-induced hypertension" (PIH) because it is more precise .
In 2008, the Society of Obstetricians and Gynecologists of Canada (SOGC) released revised guidelines that simplified the classification of hypertension in pregnancy into 2 categories, preexisting or gestational, with the option to add "with preeclampsia" to either category if additional maternal or fetal symptoms, signs, or test results support this .
Chronic hypertension is defined as blood pressure exceeding 140/90 mm Hg before pregnancy or before 20 weeks' gestation. When hypertension is first identified during a woman's pregnancy and she is at less than 20 weeks' gestation, blood pressure elevations usually represent chronic hypertension.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 20 Years 至 35 Years(Adult)
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •Pregnant women (primigravidas).
- •Age between 20 and 35 years old.
- •Live fetus.
排除标准
- •Women younger than 20 years old and older than 35 years old
- •Intrauterine fetal death.
- •History of pre-gestational hypertension.
- •History of hormonal disorders (thyroid gland disorders and hyperprolactinemia).
- •Polycystic ovary syndrome.
- •Signs or symptoms of hyper-androgenism (hirsutism, acne, oily skin, etc.).
- •Diabetes mellitus.
- •Drug use except ordinary supplementation (iron, folic acid).
结局指标
主要结局
serum androgen levels as a marker for the severity of preeclampsia
时间窗: 1 week
assess if serum androgen levels could be used as a marker for the severity of preclampsia
次要结局
未报告次要终点
研究者
Joseph Adel Ibrahiem Johny
Principal Investigator
Ain Shams University
