Effects of St. John's Wort on the Effectiveness of Oral Contraceptives

Not Applicable

Completed

• Conditions: Contraception

• Registration Number: NCT00026013
• Lead Sponsor: National Center for Complementary and Integrative Health (NCCIH)

Brief Summary

The purpose of this study is to evaluate the effects of a common herbal remedy, St. John's Wort, on the effectiveness of birth control pills. St. John's Wort has recently been shown to increase metabolism of some drugs. If it could increase metabolism of oral contraceptives as well, it may increase the risk of contraceptive failure and unintended pregnancy. Study participants will be evaluated for risk of ovulation on oral contraceptives before and during simultaneous therapy with St. John's Wort.

Detailed Description

See Brief Summary

Study Timeline

• Study First Submitted: 2001-11-05
• Study First Submitted QC: 2001-11-05
• Study First Posted: 2001-11-06
• Study Start: 2002-01
• Study Completion: 2004-01
• Status Verified: 2006-07
• Last Update Submitted: 2006-08-17
• Last Update Posted: 2006-08-18

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Female
• Target Recruitment: 25

Inclusion Criteria

• Women taking or willing to take low dose oral contraceptives for 5 months
• No contraindications to hormonal contraception

Exclusion Criteria

Not provided

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Trial Locations

Locations (1)

Columbia University Department of Obstetrics & Gynecology; 🇺🇸 New York, New York, United States