NL-OMON52657招募中不适用
Adoptive therapy with TCR gene-engineered T cells to treat patients with MAGE-C2-positive melanoma and head and neck cancer. - MAGE-C2 TCR T cell therapy
适应症
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 20
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
入排标准
- 年龄范围
- 18 至 99（—）
入选标准
- •Patients must be >= 18 years of age.
- •Patients must have:
- •- inoperable stage IIIc or stage IV cutaneous melanoma, including ocular or
- •mucosal melanoma, progressing after standard of care therapy, or
- •recurrent/metastatic HNSCC
- •Patients must be HLA-A2 positive.
- •The primary tumor and/or metastasis have to be positive for MAGE-C2
- •Patients must have a clinical performance status of ECOG 0 or 1.
- •Patients of both genders must be willing to practice a highly effective method
- •of birth control during treatment and for four months after receiving the
- •preparative regimen.
- •Patients must be able to understand and sign the Informed Consent document.
排除标准
- •Life expectancy of less than three months.
- •Requirement for systemic steroid therapy.
- •Patients who have active/symptomatic CNS metastases.
- •Patients with pleural effusion or ascites.
研究者
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