Fluid replacement with colloids and its impact on platelets, hemostasis and renal functio

Phase 3

• Conditions: E86; P74.1; R57; T81.1; T79.4; Volume depletion; Dehydration of newborn; Shock, not elsewhere classified; Shock during or resulting from a procedure, not elsewhere classified; Traumatic shock

• Registration Number: DRKS00004452
• Lead Sponsor: Medizinische Universität Wien, Abteilung für Anästhesie, Intensivmedizin und Schmerztherapie

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2012-10-30
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Complete
• Sex: Male
• Target Recruitment: 25

Inclusion Criteria

male
ASA-Classification I
Age > 18 and < 65
no medication intake
no renal function disease

Exclusion Criteria

blood group 0, liver disease, hematological disease, BMI over 25kg/m2, allergy

Study & Design

• Study Type: interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Three currently available kolloids will be analysed for its impact on platelet function. Poweranalysis was performed based on the ADP induced aggregation Area under the Curve - AUC in Multiple Electrode Aggregometry (MEA). Differences in aggregation before and after infusion will be analysed in all three groups. Changes under 12 units are set equally. <br>

Secondary Outcome Measures

Name	Time	Method
All other parameters will be analysed before and after the infusion. These are other hemostasis parameters from ROTEM and renal function test parameters.<br><br>