ISRCTN70547688已完成未知
Intervention study on the effect of quercetin on biomarkers for cardiovascular syndrome in patients with different apolipoprotein E (ApoE) isoforms
Max Rubner Institute (Germany)0 个研究点目标入组 49 人开始时间: 2008年8月19日最近更新:
适应症
试验速览
- 阶段
- 未知
- 状态
- 已完成
- 发起方
- 入组人数
- 49
研究概览
简要总结
2013 results in: https://www.ncbi.nlm.nih.gov/pubmed/22118955 (added 14/06/2019)
研究设计
- 研究类型
- Interventional
入排标准
- 性别
- Male
入选标准
- •1. Healthy male volunteers
- •2. Aged 45 - 69 years
- •3. Member of the Metabolic Intervention Cohort Kiel (MICK)
- •4. Homozygous for ApoE 3 or ApoE 4, or ApoE 3/4 heterozygous
- •5. Written informed consent
排除标准
- •1. Participation in a clinical study with a medicament or a medicinal product within the last 30 days or simultaneous participation in another clinical examination
- •2. Inability to understand and to comply with the study protocol
- •3. Known metabolic or gastro-intestinal diseases, which affect the absorption, metabolism or excretion of food or food components
- •4. Condition after surgery of the gastro-intestinal tract, which affect gastro-intestinal motility
- •5. Haemoglobin less than 12 g/dL
- •6. Ferritin less than 35 µg/L
- •7. Latex allergy
- •8. Diabetes (fasting glucose levels greater than 125 mg/dl after repeated determination)
- •9. Surgery within the last three months, which still affects the current state of health
- •10. Deformation of finger tips, which inhibits correct recording of the EndoPAT device (measures a Peripheral Arterial Tone [PAT™] signal for assessment of endothelial dysfunction)
- •11. Illness of thyroid gland, which has metabolic and/or cardiovascular effect
- •12. Known hepatitis B, hepatitis C, human immunodeficiency virus (HIV) infection or chronic liver disease
- •13. Kidney malfunction
- •14. Psychiatric disorders, epilepsy, risk of suicide
- •15. Drug or alcohol abuse
- •16. Intake of nitrate and/or calcium antagonists, which affect the blood pressure
- •17. Intake of drugs affecting the absorption, metabolism or excretion of food components or the gastro-intestinal motility
- •18. Intake of hormone preparations, particularly cortisone
- •19. Eating disorders, anorexia, bulimia, unusual outsider dietary habits
- •20. Legal incapacity
研究者
相似试验
已完成
不适用
Diabetes Intervention for Agenda Trial: study of the efficacy of a patient-orientated agenda (produced by the PACE-D tool) for use in a diabetes clinical consultatioDiabetes mellitusTopic: Diabetes Research NetworkSubtopic: BothDisease: Diabetic ControlNutritional, Metabolic, EndocrineISRCTN75070242Royal Devon and Exeter NHS Foundation Trust (UK)120
已完成
3 期
A phase III study to determine the role of a second autologous stem cell transplant as consolidation therapy in patients with relapsed multiple myeloma following prior high dose chemotherapy and autologous stem cell rescueRelapsed Multiple MyelomaMyelomaCancerISRCTN60123120The Leeds Teaching Hospitals NHS Trust (UK)293
已完成
不适用
Does a six week supervised Exercise programme improve fitness and well-being in Post Intensive Care patients? (EPIC)Any patient who has been a patient on ICU (general) for 48 hours or moreISRCTN11853373Abertawe Bro Morgannwg University (ABMU) Health Board (UK)60
已完成
不适用
Regenerative effects of erythropoietin in burn and scald injuriesThermal injuriesInjury, Occupational Diseases, PoisoningISRCTN95777824Munich Technical University (Technische Universitaet Munchen) (Germany)116
已完成
不适用
A study of the effectiveness of the Air Quality Health Index (AQHI) in reducing harmful effects of air pollution on the heart and lungs in adults 55 and overCardiac and respiratory healthSigns and SymptomsSymptoms and signs involving the circulatory and respiratory systemsISRCTN26552763Health Canada72