Physiologic and Clinical Effect of High-flow Oxygen Therapy in Tracheostomized Patients With Prolonged Mechanical Ventilation Undergoing Weaning Trials
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- High Flow Oxygen Therapy
- Sponsor
- National Taiwan University Hospital
- Enrollment
- 10
- Locations
- 1
- Primary Endpoint
- ventilation perfusion distribution measurement
- Status
- Completed
- Last Updated
- 2 years ago
Overview
Brief Summary
This study is aimed at patients who have been admitted to the respiratory care center of this hospital who meet the PMV conditions (defined as continuous use of the ventilator for at least ten days) who are about to receive the ventilator out of training. After obtaining the explanatory consent, they will undergo continuous complete Before and after spontaneous breathing training, collect various relevant physiological data of lung volume and ventilation perfusion distribution, and analyze and predict the correlation of ventilator detachment.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Be at least 20 years old, have undergone tracheotomy, have been using a ventilator for at least 10 days, and have stable vital signs.
Exclusion Criteria
- •Age \<20 years
- •The oxygen concentration (FiO2) provided by the respirator exceeds 60%
- •Blood pressure-systolic blood pressure below 70 mmHg
- •Heartbeat is lower than 50/min or higher than 160/min
- •Respiration rate is higher than 50/min
- •Lack of voluntary breathing
Outcomes
Primary Outcomes
ventilation perfusion distribution measurement
Time Frame: 16 weeks
1. Within 2 hours before starting the whole day of ATC, start measuring lung volume and ventilation perfusion distribution in SIMV+PS mode. 2. Start the 72-hour ATC mode, measure once within 2 hours; measure again after 24 hours. 3. Within 2 hours before and after the completion of the 72-hour ATC conversion to the 24-hour tracheostomy tube high flow oxygen, one measurement is made. 4. Measure once within 2 hours before and after the completion of 24-hour high-flow oxygen conversion to 5 consecutive days of spontaneous breathing training. 5. After the use of high flow oxygen starts, measure it every 24 hours until the 5th day.