Saliva Profiles in Children With Congenital Heart Disease

Not Applicable

Completed

• Conditions: Cardiac Disease; Dental Caries
• Interventions: Other: saliva

• Registration Number: NCT03457974
• Lead Sponsor: Istanbul University

Brief Summary

The purpose of this study was to evaluate whether there are relationships between the salivary oxidative stress status of children with CHD directly dental caries including gender, age, salivary flow rate, salivary pH, salivary buffering capacity and drug intake such as angiotensin-converting enzyme (ACE) inhibitors. If such relationships exist, they might be employed to patient caries -prevention treatment.

Detailed Description

Using heart failure medications may cause low salivary pH and buffering capacity.As improved oral health is a priority for cardiac patients, it is necessary that they attend dental clinics for regular follow up.

This cross sectional study was carried out with 42 CHD and 42 healthy children who applied to Istanbul University, Faculty of Dentistry, Department of Pedodontics. Gender, age, general health and medications, and caries scores (dfs/DMFS) were recorded. Unstimulated saliva was collected from the participants and were assessed for the salivary secretion rate, salivary buffering capacity, pH, protein levels, superoxide dismutase (SOD), ferric reducing antioxidant power (FRAP), the thiobarbituric acid reactive substances (TBARS), protein carbonyl, protein thiols, total sialic acid.

Study Timeline

• Study Start: 2011-01-01
• Primary Completion: 2012-01-01
• Study Completion: 2012-01-01
• Study First Submitted: 2018-02-23
• Status Verified: 2018-03
• Study First Submitted QC: 2018-03-01
• Last Update Submitted: 2018-03-01
• Study First Posted: 2018-03-08
• Last Update Posted: 2018-03-08

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 84

Inclusion Criteria

• 3-12 years
• Caridac problems

Exclusion Criteria

• other ages
• syndromes
• other systemic diseases

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
helathy children	saliva	42 children
congenital heart disease	saliva	42 patients

Primary Outcome Measures

Name	Time	Method
pH	2 hour	pH
salivary secretion rate	2 hour	salivary secretion rate
salivary buffering capacity	2 hour	salivary buffering capacity

Secondary Outcome Measures

Name	Time	Method
protein levels of saliva	2 hour	protein levels
superoxide dismutase (SOD)	2 hour	superoxide dismutase (SOD)
ferric reducing antioxidant power (FRAP)	2 hour	ferric reducing antioxidant power (FRAP)
the thiobarbituric acid reactive substances (TBARS)	2 hour	the thiobarbituric acid reactive substances (TBARS)