Comparing Therapeutic Hypothermia Using External and Internal Cooling for Post-Cardiac Arrest Patients
- Conditions
- Cardiac Arrest
- Registration Number
- NCT00827957
- Lead Sponsor
- Singapore General Hospital
- Brief Summary
Controlled therapeutic hypothermia is a method of preserving neurological function post-resuscitation.It has been associated with improved functional recovery and reduced histological deficits in animal models of cardiac arrest.
- Detailed Description
Three randomized clinical studies have been reported showing improved neurological outcome and reduced mortality in post-resuscitation patients treated with hypothermia compared to controls. Of the various methods of inducing hypothermia, internal cooling using an endovascular catheter and external cooling using gel pads with a water based circulating system have shown the most promise. There have not been any studies looking at outcomes between the two methods of cooling.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 51
- Sustained return of spontaneous circulation (ROSC) after cardiac arrest, for more than 30 min
- Patients aged between 18 to 80 years.
- Patients who are hemodynamically stable, with a systolic BP > 90 mmHg with or without inotropic support.
- Patients comatose or unresponsive post-resuscitation
- Hypotension despite fluid and/or vasopressor support
- Positive pregnancy test in women below 50 years
- Premorbid status bedbound and uncommunicative
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Primary Outcome Measures
Name Time Method Survival to hospital discharge 30 days post arrest
- Secondary Outcome Measures
Name Time Method Neurological status of post-resuscitation patients 1 year post discharge
Trial Locations
- Locations (2)
National Heart Centre Singapore
🇸🇬Singapore, Singapore
Singapore General Hospital
🇸🇬Singapore, Singapore
National Heart Centre Singapore🇸🇬Singapore, Singapore