Comparison Cytokine Clearance Between Sustained Low-Efficiency Diafiltration (SLED-f) Using High Cut-off Dialyzer and High-flux Dialyzer in Septic AKI Patients
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 16
- 主要终点
- IL-6 Clearance
研究概览
简要总结
Hypercytokinemia contributes a major role in the pathogenesis and is associated with the high mortality in sepsis-related acute kidney injury(AKI). This pilot randomized controlled trial was conducted in sepsis-related AKI patients to compare the efficacy of cytokine removal including interleukin(IL)-6, IL-8, IL-10, and tumor necrotic factor(TNF)-α by six-hour SLED-f between using HCO dialyzer(HCO-SLED-f) and HF dialyzer(HF-SLED-f).
详细描述
Hypercytokinemia contributes a major role in the pathogenesis and is associated with the high mortality in sepsis-related acute kidney injury(AKI). Reductions of these cytokines have been reported to improve clinical outcomes. Online sustained low-efficiency diafiltration(SLED-f) using traditional high-flux(HF) dialyzer could remove some cytokines. Interestingly, the potential of enhancing cytokine removal by using newly designed high cut-off(HCO) dialyzer that could theoretically remove larger molecular weight solutes has never been studied in SLED-f before.This pilot randomized controlled trial was conducted in sepsis-related AKI patients to compare the efficacy of cytokine removal including interleukin(IL)-6, IL-8, IL-10, and tumor necrotic factor(TNF)-α by six-hour SLED-f between using HCO dialyzer(HCO-SLED-f,n=8) and HF dialyzer(HF-SLED-f,n=8).
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Acute kidney injury stage 3
排除标准
- •Profound hemodynamic instability with more than one inotropic drug
- •Pregnancy
- •Breast-feeding
- •Delayed receiving antibiotic up to 6 hours after beginning of septic shock.
结局指标
主要结局
IL-6 Clearance
时间窗: At 30 minutes after the treatment was started
Simultaneous pre-and post-dialyzer blood samples from arterial and venous sampling ports were collected at 30 minutes after the treatment was started for determination of dialyzer clearances.
次要结局
- Urea percentage of reduction ratio(At time 0-hour and 6-hour of the study SLED-f session)
- Beta2-microglobulin percentage of reduction ratio(At time 0-hour and 6-hour of the study SLED-f session)
- IL-10 Clearances(At 30 minutes after the treatment was started)
- TNF-α Clearances(At 30 minutes after the treatment was started)
- Intradialytic hypotension(During 6 hours of SLED-f session)
- Albumin loss in spent dialysate(During 6 hours of SLED-f session)
研究者
Khajohn Tiranathanagul
Assistant Professor
Chulalongkorn University