EFFICACY OF VIRECHANA KARMA, DASHAMOOLA TRIVRUTA TAILA MATRA BASTI AND GUDUCHYADI KASHAYA ORALLY IN THE MANAGEMENT OF ENDOMETRIOSIS - A SINGLE ARM OPEN LABELLED CLINICAL TRIAL

Introduction:

Endometriosis is defined as the presence of endometrial tissue (glands and stroma) outside the uterine cavity. It is benign but it is locally invasive, disseminates widely. Dysmenorrhea (Menstrual cramps), dyspareunia (painful intercourse), dyschezia (Obstructed defecation), dysuria (Discomfort urinating), pelvic pain and infertility are the prominent symptoms seen in women suffering from endometriosis.

Ayurveda explains that it is not always possible to name a disease in a definite term. endometriosis is not an exception for the same. Hence this disease has to be analyzed according to the Nidana Panchaka theory of Ayurveda based on the concepts of Dosha, Dushya, Srotas, Samprapti, and its management. The general treatment principles can be laid down by going through the treatment principles of Artavadushti, Pradara, Yonivyapad, Raktapitta, Gulma and Granthi. All these principles can be summarized as Shodhana therapy for Srotoshodhana and Shaman therapy as Vatanulomana and Lekhana.

Why this topic:

There is no such effective treatment in modern science other than hormonal therapy and surgery.  Hormonal therapy has its own side effects and it is not a ‘complete cure’. Laparoscopy or surgical management is not opted by most of patients due to side effects and high cost of the treatment. Keeping all this views in mind, a better, safer

and effective therapy is needed for the present society which not only resolves the chocolate cyst, but also improves related menstrual problem and enhance the normal functioning of reproductive system. Looking into the etiopathogenesis and complications of endometriosis, it requires a systemic therapy for which Ayurveda may provide a hope through Shodhana and Shamana treatment. Thus, Present study has been planned to evaluate therapeutic efficacy of VIRECHANA KARMA, DASHAMOOLA TRIVRUTA TAILA MATRA**BASTI AND GUDUCHYADI KASHAYA ORALLYin the management of endometriosis.

Aims and Objectives:

AIM

To evaluate the efficacy of Virechana followed by Dashamoola Trivruta Taila Matra Basti and Guduchyadi Kashaya orally in the management of Endometriosis.

 OBJECTIVES

1.    To assess the efficacy of the treatment protocol in VAS score of dysmenorrhea, dyspareunia and deep-seated pelvic pain.

2.    To evaluate the quality of life by using EHP-30 questionnaire.

  Materials and Methods:

In the present study total minimum 15 diagnosed patients of endometriosis based on USG parameters, fulfilling the selection criteria will be registered. Single group of the patients will be treated with Virechna Karma followed byDashamoola Trivruta Taila Matra Basti and Guduchyadi Kashaya Orally.

Duration of study:

3 months along with 1 month of follow up.

Follow up:

After completion of therapy, follow up will be done for 1 month to assess the status of patient, where patient will be asked to report.

Side Effects:

These drugs have no known unwanted effects. It is possible that it may also cause some problems that we are not aware of. Adverse Drug Reaction if any observed will be reported to the Pharmacovigilance cell of I.T.R.A., Jamnagar.

Results and Discussion:

Data generated during the above study will be presented in a systemic manner as shall be analysed and the section where the important points of the Conceptual study, Clinical study, Pharmacological study will be discussed.