Cystic fibrosis; a hereditary inflammatory process.
Completed
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 60
Inclusion Criteria
1. CF diagnosis as confirmed by sweat chloride test and/or genotyping;
2. CF-patients 2-10 years old;
Exclusion Criteria
1. CF-patients < 2 years;
2. CF-patients > 10 years;
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method PULMONARY:<br /><br>1. FEV1, FVC, RV%TLC after 3 years;<br /><br>2. Rint measurements.<br /><br>
- Secondary Outcome Measures
Name Time Method IMMUNOLOGICAL:<br /><br>1. Neutrophil markers: MoPhabs A17 and A27, CD11b, CD11a;<br /> <br>2. IL-8, sICAM1, sE-Selectin, TNFa;<br /><br>3. End tidal carbon monoxide in exhaled breath;<br /><br>MICROBIOLOGICAL:<br /> <br>4. Respiratory pathogens in culture;<br /> <br>SEROLOGICAL:<br /><br>5. Seroconversion to anti-pseudomonal antibodies;<br /><br>Clinical: <br /><br>6. Adverse events;<br /><br>7. Clinical parameters (body weight, height, fat free mass);<br /><br>8. Number of pulmonary acerbations;<br /> <br>9. Antimicrobial agent use;<br /><br>10. Quality of life questionnaire scores;<br /><br>RADIOLOGICAL:<br /><br>11. Chest radiograph scored by CF chest radiograph scoring systems.<br />