Microbiota and Carcinogenesis of Small-intestine Neuroendocrine Tumors

Recruiting

• Conditions: Small-intestine Neuroendocrine Tumors

• Registration Number: NCT06624865
• Lead Sponsor: Hospices Civils de Lyon

Brief Summary

The aim of the study is to investigate the impact of the microenvironment on tumorigenesis of small intestinal neuroendocrine tumors often located in the terminal ileum, without identified driver mutations.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2024-09-30
• Study First Submitted QC: 2024-09-30
• Study First Posted: 2024-10-03
• Study Start: 2024-11-05
• Status Verified: 2025-04
• Last Update Submitted: 2025-04-03
• Last Update Posted: 2025-04-04
• Primary Completion: 2029-10
• Study Completion: 2029-10

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 75

Inclusion Criteria

• Patient with one or more small-intestine neuroendocrine tumor with indication of surgery
• Patient with consent for the collection, storage and reuse of data associated with his/her disease
• Age ≥ 18 years at the time of inclusion
• Non-objection statement obtained for participation in the study

Exclusion Criteria

• Patients with poorly differentiated neuroendocrine carcinoma or NET (neuroendocrine tumors) of non-intestinal origin or mixed tumors (MiNEN)
• Pregnant, parturient or breast-feeding women
• Minors
• Persons deprived of liberty by judicial or administrative decision
• Adults under legal protection (guardianship, curatorship)

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Composition of microbiota	At day 1 and month 3	Determination of the composition of blood, fecal, intra- and peri-tumoral microbiota in patients undergoing surgery for small-intestine neuroendocrine tumor.

Trial Locations

Locations (1)

Edouard Herriot University Hospital; 🇫🇷 Lyon, France