Application of Neurally Adjusted Ventilatory Assist to Children After Congenital Cardiac Surgery: the Effect of Patient-ventilator Interaction, Gas Exchange and Hemodynamics
Overview
- Phase
- Phase 3
- Intervention
- Not specified
- Conditions
- Mechanical Ventilation Complication
- Sponsor
- Shanghai Jiao Tong University School of Medicine
- Enrollment
- 72
- Locations
- 1
- Primary Endpoint
- Asynchrony index and Comfort Scale
- Last Updated
- 13 years ago
Overview
Brief Summary
Neurally adjusted ventilatory assist (NAVA) is a new mode of mechanical ventilation that delivers ventilatory assist in proportion to neural effort. It was a controlled randomized single-center prospective study in order to explore the efficacy of this new mode of mechanical ventilation after corrective open-heart surgery for congenital heart disease.
Detailed Description
1. To evaluate the effect of the patient-ventilator interaction in children underwent open-heart surgery when ventilated with NAVA, compared with conventional mechanical ventilation. 2. To verify the benefits of NAVA in improving the gas exchange and hemodynamics after biventricle repair for CHD.
Investigators
Limin Zhu
Attendant doctor, Department of thoracic and cardiovascular surgery
Shanghai Jiao Tong University School of Medicine
Eligibility Criteria
Inclusion Criteria
- •patients underwent cardiac surgery with biventricle repaired
- •patients need mechanical ventilation more than 24hrs after cardiac surgery
Exclusion Criteria
- •age \>18 years
- •inappositely of catheter insertion
- •hemodynamic instability
- •coagulation disorders or bleeding
- •inclusion in other research protocol
Outcomes
Primary Outcomes
Asynchrony index and Comfort Scale
Time Frame: 2 weeks
Secondary Outcomes
- Dosage of sedatives(2 weeks)
- hemodynamics(2 weeks)
- Duration of mechanical ventilation(2 weeks)
- Gas exchange(2 weeks)
- Length of ICU stay(2 weeks)