Investigation of Specific Biomarkers in Patients With Atrial Fibrillation Who Undergo Interventional Treatment
- Conditions
- Atrial Fibrillation
- Interventions
- Diagnostic Test: Proteomic analysis by antibody microarrays
- Registration Number
- NCT05170607
- Brief Summary
The two main mechanisms for atrial fibrillation (AF) recurrence after cryoablation include Pulmonary vein (PV) reconnection and the presence of non-PV associated arrhythmic focuses. The aim of this study is to reveal the specific biomarkers by antibody microarrays.
- Detailed Description
One hundred twenty patients with atrial fibrillation will participate in the study.
They will be divided into three groups.
1. Patients with AF recurrence after the first procedure but with isolated pulmonary veins at the beginning of the second AF ablation b)patients with AF recurrence after repeat PV ablation.
2. Patients with PV-associated atrial fibrillation. The group will be included patients with freedom of atrial fibrillation after PV isolation (first or repeat procedure).
3. Healthy volunteers
Groups would be formed from patients who previously underwent atrial fibrillation ablations and whose blood samples have been taken and placed in a biobank before interventional treatment. The first step will include proteomic serum profiling using antibody microarrays in ten subjects will be split into 3 groups. The second step will include validation of selected protein biomarkers, in the total cohort (N=120).
Recruitment & Eligibility
- Status
- ACTIVE_NOT_RECRUITING
- Sex
- All
- Target Recruitment
- 120
• Patient with paroxysmal/persistent atrial fibrillation who underwent interventional treatment
- permanent AF
- contraindications to oral anticoagulation or heparin
- chronic kidney disease requiring dialysis
- untreated hypo- or hyperthyroidism
- breast feeding
- pregnancy
- chronic kidney disease requiring dialysis
- decompensated heart failure
- stroke within the last 3 months
- myocardial infarction within the last 3 months
- Percutaneous coronary intervention or Coronary Artery Bypass Grafting within the last 3 months
- active myocarditis
- artificial valve replacement surgery
- severe mitral or aortic stenosis
- coronary artery disease requiring revascularization
- heart transplant
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Arm && Interventions
Group Intervention Description Healthy volunteers Proteomic analysis by antibody microarrays - PV associated atrial fibrillation Proteomic analysis by antibody microarrays - non-PV associated arrhythmic focuses Proteomic analysis by antibody microarrays -
- Primary Outcome Measures
Name Time Method proteins after validation 1 year number of protein which will be specific for non-PV associated arrhythmic focuses group after validation
- Secondary Outcome Measures
Name Time Method proteins after screening 1 year number of protein which will be specific for non-PV associated arrhythmic focuses group after screening
Trial Locations
- Locations (1)
National Research Center for Preventive Medicine
🇷🇺Moscow, Russian Federation