Preoperative Cognitive Impairment Predicts Postoperative Delirium

Completed

• Conditions: Delirium in Old Age; Neurocognitive Disorders; Cognitive Impairment
• Interventions: Behavioral: Neuropsychological tests

• Registration Number: NCT05798767
• Lead Sponsor: Henan Provincial People's Hospital

Brief Summary

Preoperative cognitive impairment (PCI) may increase the incidence of postoperative delirium (POD), yet screening for cognitive impairment is rarely performed. This study hypothesized that Mini-Cog for preoperative cognitive impairment screening predicts postoperative delirium. Elderly patients (65 years or older) attending Henan Provincial People's Hospital during the trial period who required elective thoracic surgery were recruited into the study.

Detailed Description

We collected data points on demographics and hospital episodes through the electronic medical record the day before surgery. Cognitive function screening (Mini-Cog; the Mini-mental State Examination, MMSE), depression screening (Patient Health Questionnaire-9, PHQ-9), sleep quality assessment (Pittsburgh Sleep Quality Index, PSQI), and pain assessment (Numeric Rating Scale, NRS) were performed, and the time spent on Mini-Cog test and MMSE assessment was recorded. The Short Confusion Assessment Method (CAM) was administered once per day on postoperative days 1 to 5 to evaluate delirium.

Study Timeline

• Study Start: 2022-02-01
• Status Verified: 2023-01
• Primary Completion: 2023-01-01
• Study Completion: 2023-03-01
• Study First Submitted: 2023-03-22
• Study First Submitted QC: 2023-03-22
• Last Update Submitted: 2023-03-22
• Study First Posted: 2023-04-05
• Last Update Posted: 2023-04-05

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 150

Inclusion Criteria

1. 65 years of age or older,
2. elective thoracic surgery,
3. under general anesthesia.

Exclusion Criteria

1. history of psychiatric disorders,
2. use of any antipsychotic drugs,
3. ASA score >3
4. severe visual, hearing, or physical dysfunction unable to complete the scale
5. advanced malignant tumors of the chest with distant metastases to bone, liver, etc.,
6. history of general anesthesia surgery in the last six months.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
PCI group	Neuropsychological tests	Patients with a Mini-Cog score of 3 or less were in the PCI group
Normal group	Neuropsychological tests	Patients with a Mini-Cog score of 3 or 4 were in the normal group

Primary Outcome Measures

Name	Time	Method
delirium	February 2022 to March 2023	postoperative delirium accessed by the Short Confusion Assessment Method (CAM)

Trial Locations

Locations (1)

Henan People's Hospital; 🇨🇳 Zhengzhou, China