CTRI/2025/07/091629Not ApplicablePhase 3
Effectiveness of Platelet-rich Plasma with Strengthening Exercise versus Conventional Physiotherapy in Knee Osteoarthritis Patients.
Dr Ehsanur Rahman1 site in 1 country60 target enrollmentStarted: August 4, 2025Last updated:
Trial Snapshot
- Phase
- Phase 3
- Status
- Not Applicable
- Sponsor
- Enrollment
- 60
- Locations
- 1
- Primary Endpoint
- Pain By Numeric Pain Rating Scale(NPRS).
Study Overview
Brief Summary
This randomized controlled trial compares the effectiveness of platelet-rich plasma (PRP) injection combined with strengthening exercise versus conventional physiotherapy in knee osteoarthritis patients aged 40–70 years. The intervention duration is 8 weeks. Pain (primary outcome) will be measured using NPRS, while secondary outcomes include WOMAC, TUG test, 30-second Sit-to-Stand test, and knee range of motion using a goniometer. Follow-up will be conducted at 6 months to evaluate long-term effects.
Study Design
- Study Type
- Interventional
- Allocation
- Randomized
- Masking
- Outcome Assessor Blinded
Eligibility Criteria
- Ages
- 40.00 Year(s) to 70.00 Year(s) (—)
- Sex
- All
Inclusion Criteria
- •The inclusion criteria considered patients aged 40-70 years with knee osteoarthritis confirmed by a rheumatologist (grades I-III in the Kellgren-Lawrence score) who had pain, morning stiffness of shorter than 30 minutes, or knee crepitus.
Exclusion Criteria
- •History of malignancy, infection, active wound in the knee, NSAIDs two days prior to injection, steroid knee injection 3 weeks before the procedure, history of severe knee trauma, pregnancy.
Outcomes
Primary Outcomes
Pain By Numeric Pain Rating Scale(NPRS).
Time Frame: 8 weeks intervention, a follow up will be conducted after 6 months.
Secondary Outcomes
- Physical Function by Western Ontario and McMaster Universities Osteoarthritis Index(WOMAC) score.(Range of Motion By Standard Goniometer.)
Investigators
Sree Pallob
Jashore University of Science and Technology
Study Sites (1)
Loading locations...
Similar Trials
Recruiting
Not Applicable
Effect of PRP Injection on Voice Recovery After Benign Vocal Fold SurgeryNCT07300800Beni-Suef University64
Recruiting
Phase 3 4
Evaluate Efficacy of Platelet Rich Plasma Therapy and Agnikarma in the Management of Plantar FasciitisCTRI/2025/11/097540Dr Chintan Vipulbhai Savani40
Completed
Phase 4
Study in people with gaps between gums and teeth comparing platelet-rich fibrin and placental extract to improve gum appearance.CTRI/2025/09/094751Moturi Padmini Raj28
Recruiting
Not Applicable
PRP Plus Fractional CO₂ Laser for Acne ScarsNCT07352215Gujranwala medical college District Headquarters Hospital, Gujranwala70
Completed
Phase 2
PRP Spinoplasty for Chronic Low Back Pain With Multiple Pathologies: A Quasi-Experimental StudyNCT07268885Allmed Medical Center35