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临床试验/NCT03873688
NCT03873688已完成不适用

Effects of Expiratory Muscle Training on Cough Efficacy in Children and Adolescents With Cystic Fibrosis

Cigdem Emirza1 个研究点 分布在 1 个国家目标入组 28 人开始时间: 2019年1月2日最近更新:
适应症

试验速览

阶段
不适用
状态
已完成
发起方
入组人数
28
试验地点
1
主要终点
Cough capacity

研究概览

简要总结

Cystic fibrosis (CF) is an autosomal recessive genetic disease characterized by recurrent airway infections, affecting many systems including lung, pancreas and sweat glands. Cough is an important defense mechanism for clearing the secretions that increase in respiratory diseases. There have been studies investigating the effect of expiratory muscle training on disease groups such as chronic obstructive pulmonary disease, multiple sclerosis, parkinson's disease, and the elderly and healthy individuals. Studies that evaluating effects of expiratory muscle training in cystic fibrosis are limited in the literature. The aim of this study was to evaluate the effect of cough strength in children and adolescents with CF and the effect of expiratory muscle training program on cough strength, exercise capacity, respiratory muscle strength and quality of life.

研究设计

研究类型
Interventional
分配方式
Randomized
干预模型
Parallel
主要目的
Treatment
盲法
Single (Participant)

入排标准

年龄范围
8 Years 至 18 Years(Child, Adult)
性别
All
接受健康志愿者

入选标准

  • Diagnosed with cystic fibrosis
  • 8-18 years
  • Clinically stable during last six weeks

排除标准

  • hemoptysis
  • low saturation (SpO2<90%)
  • acute lower respiratory tract infection
  • cardiac problems (heart failure, arrhythmia, cardiomyopathy, etc.)
  • cognitive problems
  • pneumothorax

结局指标

主要结局

Cough capacity

时间窗: 6 weeks

peak expiratory flow meter

次要结局

  • Respiratory muscle strength(every two weeks)
  • Exercise capacity(6 weeks)

研究者

发起方
Cigdem Emirza
申办方类型
Other
责任方
Sponsor Investigator
主要研究者

Cigdem Emirza

Physiotherapist

Istanbul University

研究点 (1)

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