Chronic Pain in Rheumatoid Arthritis

Recruiting

• Conditions: Arthritis, Rheumatoid; Pain
• Interventions: Other: No intervention

• Registration Number: NCT05038553
• Lead Sponsor: Northwestern University

Brief Summary

The objective is to identify modifiable clinical factors and neurobiological pathways that lead to the development of chronic pain in patients with early rheumatoid arthritis. Participants will undergo quantitative sensory testing, a type of testing that involves assessing response to well-defined, quantifiable painful stimuli, at 0, 3, and 12 months. A subset of participants will also undergo magnetic resonance imaging at 0 and 12 months to assess neuroimaging markers that have previously been shown to be involved in chronic pain.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2021-08-30
• Study First Submitted QC: 2021-09-04
• Study First Posted: 2021-09-09
• Study Start: 2021-10-12
• Status Verified: 2025-04
• Last Update Submitted: 2025-04-24
• Last Update Posted: 2025-04-29
• Primary Completion: 2026-04-30
• Study Completion: 2026-04-30

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 125

Inclusion Criteria

Not provided

Exclusion Criteria

Not provided

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Patients with early rheumatoid arthritis	No intervention	-

Primary Outcome Measures

Name	Time	Method
Fibromyalgia Survey Criteria	12 months	Minimum value 0, maximum value 31; higher scores indicate worse outcomes

Trial Locations

Locations (5)

Northwestern University; 🇺🇸 Chicago, Illinois, United States

Johns Hopkins University; 🇺🇸 Baltimore, Maryland, United States

University of Colorado; 🇺🇸 Denver, Colorado, United States

University of Michigan; 🇺🇸 Ann Arbor, Michigan, United States

Hospital for Special Surgery; 🇺🇸 New York, New York, United States