effect of selenium in systemic lupus erythematosus

Phase 3

Recruiting

• Conditions: Systemic lupus erythematosus.; Systemic lupus erythematosus, unspecified; M32.9

• Registration Number: IRCT20210717051914N2
• Lead Sponsor: Ahvaz University of Medical Sciences

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 7 February 2023

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 56

Inclusion Criteria

Age 15 to 60 years
Having at least four of the clinical and immunological diagnostic criteria for systemic lupus erythematosus
Body mass index equal to and less than 35

Exclusion Criteria

Suffering from other autoimmune and rheumatological diseases
Pregnancy and breastfeeding
Severe liver diseases
Severe renal failure
Severe and active infections
Taking selenium supplements during the last two months
Recent excessive consumption of antioxidant supplements (such as vitamin C, vitamin E, omega 3, etc.) or their consumption during the intervention
History of allergy to selenium supplements
Other cancers
Body mass index above 35

Study & Design

• Study Type: interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Disease activity. Timepoint: At the beginning and after 8 weeks of intervention. Method of measurement: By completing the questionnaire to measure the severity of systemic lupus erythematosus disease activity.;Anti-double-stranded DNA antibody. Timepoint: At the beginning and after 8 weeks of intervention. Method of measurement: Using the ELISA kit.;High-sensitivity C-reactive protein. Timepoint: At the beginning and after 8 weeks of intervention. Method of measurement: Using the ELISA kit.;Glutathione peroxidase. Timepoint: At the beginning and after 8 weeks of intervention. Method of measurement: Using the ELISA kit.;Malondialdehyde. Timepoint: At the beginning and after 8 weeks of intervention. Method of measurement: Using the ELISA kit.;Total antioxidant capacity. Timepoint: At the beginning and after 8 weeks of intervention. Method of measurement: Using the ELISA kit.