Phase I Study Characterizing Effects of Hallucinogens and Other Drugs on Mood and Performance
试验速览
- 阶段
- 1 期
- 状态
- 已完成
- 入组人数
- 20
- 试验地点
- 1
- 主要终点
- Rating of "Drug Liking" on the End of Day Questionnaire
研究概览
简要总结
This non-treatment study will investigate the effects on mood and performance caused by hallucinogens and other psychoactive compounds.
详细描述
Twenty volunteers between 21-50 years old will each participate in 16 total sessions, including sessions for: screening, preparation, experiment/drug, immediate follow-ups, a 1-month follow-up and 1 post completion urine collection. On each of five experimental session participants will orally ingest capsules of either a placebo or varying doses of one of 18 different psychoactive compounds.
Subjective drug effects will be examined with methods previously used by this laboratory for characterizing the effects of psychoactive substances from a variety different classes. Volunteers will swallow capsules containing various doses of drugs, complete tasks during the session, and rate effects of the drug and complete questionnaires at the end of each session as described below.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- Triple (Participant, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 21 Years 至 50 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Be 21 to 50 years old
- •Have given written informed consent
- •Have a high school level of education
- •Have a self-reported interest in psychedelic drugs and altered states of consciousness
- •Have used classic, serotonergic hallucinogens or dissociative anesthetic hallucinogens (e.g., LSD, psilocybin mushrooms, ayahuasca, ketamine, PCP) without untoward effects. Volunteers must report "liking" of psychedelic and psychedelic-like drugs and report having used hallucinogens at least 5 times in their lifetime and at least once within the last 2 years
- •Agree to consume approximately the same amount of caffeine-containing beverage (e.g., coffee, tea) that he/she consumes on a usual morning, before arriving at the research unit on the mornings of drug session days. If the volunteer does not usually consume caffeinated beverages, he or she must agree not to do so on session days
- •Cigarette smokers must agree to abstain from smoking on session days from 1 hour before drug administration until at least 6 hours after drug administration
- •Agree to refrain from using any psychoactive drugs, including alcoholic beverages, within 24 hours of each drug administration. Exceptions include daily use of caffeine and nicotine.
- •Be healthy and psychologically stable as determined by screening for medical problems via a personal interview, a medical questionnaire, a physical examination, an electrocardiogram (ECG), and routine medical blood and urinalysis laboratory tests
- •Agree that for one week before each session, he/she will refrain from taking any nonprescription medication, nutritional supplement, or herbal supplement except when approved by the study investigators. Exceptions will be evaluated by the study investigators and will include acetaminophen, non-steroidal anti-inflammatory drugs, and common doses of vitamins and minerals
- •Agree not to take any PRN prescription medications on the mornings of the sessions
- •Be willing and able to participate
- •Exclusion criteria:
- •Women who are pregnant (as indicated by a positive urine pregnancy test assessed at intake and before each drug session) or nursing; women who are of child-bearing potential and sexually active who are not practicing an effective means of birth control
- •Cardiovascular conditions: coronary artery disease, stroke, angina, uncontrolled hypertension, a clinically significant ECG abnormality (e.g., atrial fibrillation), or TIA in the past year
- •Epilepsy with history of seizures
- •Insulin-dependent diabetes; if taking oral hypoglycemic agent, then no history of hypoglycemia
- •Currently taking psychoactive prescription medication on a regular (e.g., daily) basis
- •Currently taking on a regular (e.g., daily) basis any medications having a primary centrally-acting pharmacological effect on serotonin neurons or medications that are MAO inhibitors. For individuals who have intermittent or PRN use of such medications, sessions will not be conducted until at least 5 half-lives of the agent have elapsed after the last dose
- •More than 20% outside the upper or lower range of ideal body weight
- •Psychiatric
排除标准
- •Current or past history of meeting DSM-IV criteria for schizophrenia, psychotic disorder (unless substance-induced or due to a medical condition), or bipolar I or II disorder
- •Current severe obsessive-compulsive disorder, dysthymic disorder, or panic disorder.
- •Current, severe, major depression
- •Have a first or second degree relative with schizophrenia, psychotic disorder (unless substance induced or due to a medical condition), or bipolar I or II disorder
- •Currently meets DSM-IV criteria for dissociative disorder, anorexia nervosa, bulimia nervosa, or other psychiatric conditions judged to be incompatible with establishment of rapport or safe exposure to study compounds
研究组 & 干预措施
Male volunteers
Hallucinogens and psychoactive substances will be administered via capsule. Results will be compared between male and female participants.
干预措施: Hallucinogens and psychoactive substances (Drug)
Female volunteers
Hallucinogens and psychoactive substances will be administered via capsule. Results will be compared between male and female participants.
干预措施: Hallucinogens and psychoactive substances (Drug)
结局指标
主要结局
Rating of "Drug Liking" on the End of Day Questionnaire
时间窗: Completed at the end of the experimental session (approximately 8 hours after capsule administration)
Volunteer-completed questionnaire assesses the subjective liking of the drug condition for the session
次要结局
- Hallucinogen Rating Scale(Completed at the end of the experimental session (approximately 8 hours after capsule administration))