Bintrafusp alfa and Doxorubicin Hydrochloride in Treating Patients With Advanced Sarcoma.

Phase 1

• Conditions: retroperitoneal sarcomas; MedDRA version: 20.0Level: LLTClassification code 10039494Term: Sarcoma NOSSystem Organ Class: 100000004864; MedDRA version: 20.0Level: LLTClassification code 10077289Term: Retroperitoneal sarcomaSystem Organ Class: 100000004864; Therapeutic area: Diseases [C] - Cancer [C04]

• Registration Number: EUCTR2021-001085-37-FR
• Lead Sponsor: Institut Bergonié

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2021-07-22
• Last Update Posted: 10 June 2024

Recruitment & Eligibility

• Status: Authorised-recruitment may be ongoing or finished
• Sex: All
• Target Recruitment: 66

Inclusion Criteria

1. Patients with retroperitoneal sarcoma histologically confirmed and reviewed by the RRePS Network (Réseau de Référence en Pathologie des Viscères et des tissus mous) as recommended by the French National Cancer Institute(Inca),
2. For TLS status determination: available archived FFPE (Formalin-Fixed Paraffin-Embedded) tumor tissue sample. In case of archived material is not available, presence of tumor lesion that can be biopsied for research purpose,
3. Presence of mature tertiary lymphoid structures. Except if presence of TLS have been already confirmed by Biopathological platform at Bergonié Institute, presence of TLS should be confirmed by central review based on FFPE (Formalin-Fixed Paraffin-Embedded) tumor tissue sample (archived or newly obtained by biopsy for research purpose). Note that the presence of TLS could be determined by central analysis if not available before,
4. Non-metastatic and resectable disease,
5. At least one lesion that can be biopsied for research purpose,
6. No prior treatment for the disease under study,
7. Age = 18 years,
8. Eastern Cooperative Oncology Group (ECOG) performance status (PS) = 1,
9. Life expectancy > 3 months,
10. Patients must have measurable disease (lesion in previously irradiated field can be considered as measurable if progressive at inclusion according to RECIST v1.1) defined as per RECIST v1.1 with at least one lesion that can be measured in at least one dimension (longest diameter to be recorded) as =10 mm with spiral CT scan.
11. Adequate hematological, renal, metabolic and hepatic function:
a. Hemoglobin = 8.0 g/dl; leucocytes = 2.0 G/l, absolute neutrophil count (ANC) > 1.0 G/l and platelet count > 100 G/l,
b. Alanine aminotransferase (ALT) and aspartate aminotransferase (AST) = 2.5 x upper limit of normality (ULN) ,
c. Total bilirubin = 1.5 x ULN
d. Albumin = 25g/l
e. Serum creatinine = 1.5 x ULN OR Calculated creatinine clearance (CrCl) = 60 ml/min (calculated per institutional standard) for subject with creatinine levels > 1.5 x ULN.
f. Thyroid function within normal laboratory ranges (TSH, free T3, free T4)
12. Left ventricular ejection fraction (LVEF) = 50% assessed by ECHO or MUGA within 6 months from study entry,
13. Women of childbearing potential must have a negative serum pregnancy test within 7 days prior to study entry. Pregnancy test (serum or urine) should be repeated within 72 hours prior to receiving the first dose of trial medication.
14. Both women and men must agree to use a highly effective method of contraception throughout the treatment period and for one year after discontinuation of treatment for women and 4 months for men.
15. No prior or concurrent malignant disease diagnosed or treated in the last 2 years except for adequately treated in situ carcinoma of the cervix, concomitant endometrial carcinoma stage IA grade 1, basal or squamous skin cell carcinoma, or in situ transitional bladder cell carcinoma,
16. Recovery to grade = 1 from any adverse event (AE) derived from previous treatment (excluding alopecia of any grade and non-painful peripheral neuropathy grade = 2) according to the National Cancer Institute Common Terminology Criteria for Adverse Events (NCI-CTCAE, version 5),
17. Voluntarily signed and dated written informed consent prior to any study specific procedure,
18. Patients with a social security in compliance with the French law.
Are the trial subjects under 18? no
Number of subjects for this age range:
F.1.2 Adults (18-64 years) yes

Exclusion Criteria

1. Previous treatment for retroperitoneal sarcoma including surgery, chemotherapy or radiotherapy
2. Previous treatments with doxorubicin, daunorubicin, epirubicin, idarubicin and/or other anthracyclines or anthracenediones at the maximum cumulative dose,
3. Known hypersensitivity to any involved study drug or any of its formulation components,
4. Has an active or ongoing infection requiring systemic therapy,
5. Known central nervous system malignancy (CNS),
6. Women who are pregnant or breast feeding,
7. Has known active hepatitis B or hepatitis C,
8. Has a known history of Human Immunodeficiency Virus (HIV),
9. Previous enrolment in the present study,
10. Patient unable to follow and comply with the study procedures because of any geographical, social or psychological reasons,
11. Has received a live attenuated vaccine or a live vaccine within 30 days prior to the first dose of trial treatment,
Note: the killed virus vaccines used for seasonal influenza vaccines for injection are allowed; however intranasal influenza vaccines (e.g., FluMist®) are live attenuated vaccines and are not allowed.
12. Uncontrolled or significant cardiovascular disease including, but not limited to, any of the following:
a. Myocardial infarction or stroke/transient ischemic attack within the 6 months prior to study entry.
b. Uncontrolled angina within the 3 months prior to study entry.
c. Any history of clinically significant arrhythmias (such as ventricular tachycardia, ventricular fibrillation, or torsades de pointes, or poorly controlled atrial fibrillation).
d. Corrected QT (QTc) prolongation > 480 msec.
e. History of other clinically significant cardiovascular disease (i.e., cardiomyopathy, congestive heart failure with New York Heart Association [NYHA] functional classification III-IV, pericarditis, significant pericardial effusion, significant coronary stent occlusion, poorly controlled venous thrombus).
13. Uncontrolled or significant renal disease including, but not limited to, any of the following:
a. Acute or uncontrolled urinary infection at study entry,
b. Hemorrhagic cystitis at study entry,
c. Presence of blood on dipstick at study entry,
d. Vesical atony,
e. Known urinary tract obstruction.
14. Patients with known history of active inflammatory bowel diseases, including those with small or large intestine inflammation, such as Crohn’s disease or ulcerative colitis, will be excluded from the study,
15. Has received systemic antibiotics within 14 days before the first dose of study treatment. Participants receiving prophylactic antibiotics (e.g., for prevention of a urinary tract infection or chronic obstructive pulmonary disease) are eligible.
16. History of organ transplant, including allogeneic stem cell transplantation.
17. Receiving probiotics as of the first dose of study treatment.
18. Has an active autoimmune disease
- Patients with diabetes type I, vitiligo, psoriasis, hypo- or hyperthyroid disease not requiring immunosuppressive treatment are eligible,
- Patients requiring hormone replacement with corticosteroids are eligible if the steroids are administered only for the purpose of hormonal replacement and at dose = 10 mg or 10 mg equivalent prednisone day,
- Administration of steroids through a route known to result in a minimal systemic exposure (topical, intranasal, intra-ocular, intra-articular or inhalation) are acceptable.
19. Evidence of interstitial lung disease, history of interstitial lung disease, or active, noninfectious

Study & Design

• Study Type: Interventional clinical trial of medicinal product
• Study Design: Not specified