CTIS2024-516163-88-00进行中（未招募）1 期
Reperfusion with P2Y12 inhibitors in addition to mechanical thrombectomy for perfusion imaging selected acute stroke patients : a multicentric randomized controlled trial. - MMI_2020_35
试验速览
- 阶段
- 1 期
- 状态
- 进行中（未招募）
- 入组人数
- 368
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
入排标准
- 年龄范围
- 18 至 65+（—）
- 性别
- All
入选标准
- •Age 18 or older, Anterior circulation intracanial large artery occlusion isolated (Intracranial ICA and/or MCA) proved on CTA or MRA, Symptoms onset < 24h at imaging, Indication for MT and fulfillment of the following brain imaging criteria : 1. Perfusion imaging: An initial infarct volume (ischemic core on DWI or CTP calculated by the RAPID software) of less than 70 ml, a ratio between the critically hypoperfused lesion volume (calculated by RAPID with a TMax>6s) and initial infarct volume of 1.8 or more, and an absolute difference between those 2 volumes of 15 ml or more. OR (if perfusion imaging not available or uninterpretable) : 2. CORE CLINICAL MISMATCH: Core calculated on DWI by RAPID, <25 mL if NIHSS 6-20 and <50 mL if NIHSS>20 OR (if RAPID results are not considered reliable by the clinician) : 3. CORE CLINICAL MISMATCH according to the clinician evaluation, Pre-stroke mRS = 2, NIHSS = 6
排除标准
- •Contraindication to MT, VKA oral anticoagulation with INR >1.7, Curative heparin or direct oral anticoagulants (DOACs) in previous 48 hours, Platelet count <100 000/ mm3, Women with childbearing potential (15-49 years old), Patient benefiting from a legal protection, Non-membership of a national insurance scheme, Opposition of the patient or (in case of inclusion as a matter of urgency) of the trustworthy person, Participation in another study regarding AIS care interfering with this study, Patient over 80 years old with >10 microbleeds on pre-treatment MRI, Pre-existing dependency with mRS =3, Known tandem ICA-MCA occlusions requiring stenting, ASPECT<6 on NCCT or DWI-MRI, Known hypersensitivity to cangrelor or to any of the excipients (mannitol, sorbitol), History of previous intracranial hemorrhage, Evidence of active bleeding or acute trauma (fracture) on examination, Recent surgery with a significant risk of bleeding
研究者
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