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Safety and Tolerability of Vildagliptin Versus Placebo in Patients With Type 2 Diabetes and Moderate or Severe Renal Insufficiency (28 Week Extension)

Phase 3
Completed
Conditions
Diabetes Mellitus, Type 2
Renal Insufficiency
Interventions
Drug: Placebo
Registration Number
NCT00765830
Lead Sponsor
Novartis
Brief Summary

This clinical trial is designed to provide additional information on the safety and tolerability of vildagliptin (50 mg once daily (qd)) when used in patients with type 2 diabetes mellitus (T2DM) and moderate or severe renal insufficiency

Detailed Description

Not available

Recruitment & Eligibility

Status
COMPLETED
Sex
All
Target Recruitment
349
Inclusion Criteria
  • Complete the core study
Exclusion Criteria
  • Did not comply with core study requirements

Study & Design

Study Type
INTERVENTIONAL
Study Design
PARALLEL
Arm && Interventions
GroupInterventionDescription
1vildagliptin50mg qd vildagliptin
2PlaceboPlacebo
Primary Outcome Measures
NameTimeMethod
To evaluate the safety and tolerability in patients with T2DM and moderate or severe renal insufficiency over 52 weeks of treatment52 weeks
Secondary Outcome Measures
NameTimeMethod
To explore the efficacy of vildagliptin (50 mg qd) versus placebo in patients with T2DM and moderate or severe renal insufficiency52 weeks

Trial Locations

Locations (89)

Hospital de la Ribera

🇪🇸

Alzira, Spain

Hospital San Pedro de Alcantara

🇪🇸

Caceres, Spain

Clinica Mediterranea de Neurociencias

🇪🇸

Alicante, Spain

Hospital Clinic I Provincial de Barcelona

🇪🇸

Barcelona, Spain

Centro de Salud Begonte

🇪🇸

Begonte, Spain

Hospital Universitario Reina Sofia

🇪🇸

Cordoba, Spain

Ciutat Sanitaria I Universitaria de Bellvitge

🇪🇸

Hospitalet de Llobregat, Spain

Hospital General de Jerez de La Frontera

🇪🇸

Jerez de La Frontera, Spain

Hospital Son Dureta

🇪🇸

Palma De Mallorca, Spain

Complejo Universitario de San Carlos

🇪🇸

Madrid, Spain

Hospital de Merida

🇪🇸

Merida, Spain

Consorci Hospitalari Parc Tauli

🇪🇸

Sabadell, Spain

Hospital Clinico Universitario Santiago de Compostela

🇪🇸

Santiago de Compostela, Spain

Eap El Remei - Vic

🇪🇸

Vic, Spain

ME3PLUS Clinical Trials

🇸🇪

Goteborg, Sweden

Njurmedicin, Sahlgrenska Univ.sjukhuset

🇸🇪

Goteborg, Sweden

Metabolmottagningen, Lasarettet, Kristianstad

🇸🇪

Kristianstad, Sweden

Ladulaas Kliniska Studier

🇸🇪

Skene, Sweden

VO Endokrinologi/Diabetologi Universitetssjukhuset

🇸🇪

Lund, Sweden

Clinica de Fracturas y Ortopedia

🇦🇷

Buenos Aires, Argentina

Hospital Juan Ramon Vidal

🇦🇷

Corrientes, Argentina

Hospital Teodoro Alvarez

🇦🇷

Buenos Aires, Argentina

Instituto Medico Especializado IME

🇦🇷

Buenos Aires, Argentina

Hospital Zenon J. Santillan

🇦🇷

San Miguel de Tucuman, Argentina

M V Hospital for Diabetes and Diabetic Research Center

🇮🇳

Chennai, India

City Clinical Hospital No.11

🇷🇺

Moscow, Russian Federation

Gujarat Endocrine Centre

🇮🇳

Ahmedabad, India

Coimbatore Diabetes Foundation

🇮🇳

Coimbatore, India

S.R. Kalla Memorial Gastro & General Hospital

🇮🇳

Jaipur, India

City polyclinic # 17, City Diabetic Centre #3

🇷🇺

Saint Petersburg, Russian Federation

Site Management Organisation of Clinical Trials Centers

🇷🇺

Smolensk, Russian Federation

Krestovsky Island Medical Institute

🇷🇺

Saint Petersburg, Russian Federation

Tyumen State Medicine Academy

🇷🇺

Tyumen, Russian Federation

Clinica Reina Fabiola

🇦🇷

Cordoba, Argentina

MSUMD on the base of City Clinical Hospital #67

🇷🇺

Moscow, Russian Federation

Instituto de Investigaciones Clinicas de Mar del Plata

🇦🇷

Buenos Aires, Argentina

Heidelberg Repatriation Hospital

🇦🇺

Heidelberg Heights, Australia

The Queen Elizabeth Hospital

🇦🇺

Woodville, South Australia, Australia

St Vincent's Hospital (Melb)

🇦🇺

Victoria, Australia

Keogh Medical Research Institute

🇦🇺

Nedlands Perth, Australia

SA Endocrine Clinical Research

🇦🇺

Keswick, Australia

ERS Endocrine Research Society

🇨🇦

Vancouver, British Columbia, Canada

Co Medica Research Network Inc.

🇨🇦

Courtice, Ontario, Canada

Health Sciences Centre - Diabetes Research Group

🇨🇦

Winnipeg, Canada

Hopital Maisonneuve-Rosemont

🇨🇦

Quebec, Canada

Centre de Recherche de Laval

🇨🇦

Laval, Canada

Ultra Med Inc.

🇨🇦

Pointe-Claire, Quebec, Canada

Private Office (Gottesman)

🇨🇦

Ontario, Canada

Clínica Vía San Juan

🇨🇷

Cartago, Costa Rica

Clínica de Endocrinología y Diabetes

🇨🇷

San Jose, Costa Rica

Hospital Clínica Bíblica

🇨🇷

San Jose, Costa Rica

Clínica San Agustín

🇨🇷

San Jose, Costa Rica

Satakunnan Keskussairaala

🇫🇮

Pori, Finland

Mediwest Research Center

🇫🇮

Seinajoki, Finland

Tampereen lääkärikeskus Oy, Koskiklinikka

🇫🇮

Tampere, Finland

Cabinet du Dr Arnou

🇫🇷

Angers, France

Hôpital Docteur Duchenne

🇫🇷

Boulogne-sur-Mer, France

Cabinet du Dr Giraud Philippe

🇫🇷

Angers, France

Cabinet médical

🇫🇷

Laval, France

Hopital Albert Michallon

🇫🇷

Grenoble cedex 9, France

Praxis Dr. Merker

🇩🇪

Dormagen, Germany

Hopital Edouard Herriot

🇫🇷

Lyon, France

Hopital Dupuytren

🇫🇷

Limoges Cedex, France

Praxis Dr. Maxeiner

🇩🇪

Bad Kreuznach, Germany

Zentralklinikum Augsburg

🇩🇪

Augsburg, Germany

Univ.-Klinikum Erlangen

🇩🇪

Erlangen, Germany

Praxis Dr. Fischer

🇩🇪

Darmstadt, Germany

Universitaetsklinik Charitè

🇩🇪

Berlin, Germany

Kardiol. Gemeinschaftspraxis PD Dr. Winkelmann

🇩🇪

Frankfurt, Germany

Medizinische Hochschule Hannover

🇩🇪

Hannover, Germany

Universitätsklinikum Frankfurt

🇩🇪

Frankfurt, Germany

Friedrich Schiller Universitaet Jena

🇩🇪

Jena, Germany

CRS Clinical Research Services Gmbh

🇩🇪

Kiel, Germany

I. Medizinische Univ.-Klinik

🇩🇪

Kiel, Germany

Praxis Dr. Hennig

🇩🇪

Meissen, Germany

Praxis Dr. Schoell

🇩🇪

Nuernberg, Germany

Univ.-Klinikum München, Campus Innenstadt

🇩🇪

München, Germany

Praxis Dr. Grimm

🇩🇪

Muenchen, Germany

Forschungszentrum Ruhr, KliFoCenter GmbH

🇩🇪

Witten, Germany

Universitaetsklinik im Luitpold-Krankenhaus

🇩🇪

Wuerzburg, Germany

Meenakshi Mission Hospital & Research Centre

🇮🇳

Madurai, India

Diabetes Clinic & Research Centre

🇮🇳

Nagpur, India

Storoklinikken

🇳🇴

Oslo, Norway

City Clinical Hospital #1

🇷🇺

Moscow, Russian Federation

St. Olavs Hospital, Endokrinologisk seksjon

🇳🇴

Trondheim, Norway

City Clinical Hospital #6

🇷🇺

Chelyabinsk, Russian Federation

MSU of Medicine and Dentistry on the base of CityHospital 23

🇷🇺

Moscow, Russian Federation

Saint-Petersburg State Pavlov's Medical University

🇷🇺

Saint-Petersburg, Russian Federation

Saint- Petersburg State Mtchnikov's Medical Academy

🇷🇺

Saint-Petersburg, Russian Federation

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