Title: Effect of Clonidine on Post-operative Nausea and Vomiting in Breast Cancer Surgery

Phase 2

Conditions: D05.10
Breast Cancer.
Intraductal carcinoma in situ of unspecified breast

Registration Number: IRCT20141009019470N99

Lead Sponsor: Shiraz University of Medical Sciences

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Pending

Sex: Female

Target Recruitment: 68

Inclusion Criteria

Patients Candidate for Breast Cancer Surgery
Ages 15 to 70 years
ASA Class I-II
General Anesthesia

Exclusion Criteria

A history of postoperative nausea and vomiting
Patients who have received antiemetic drugs such as ondansetron or dexamethasone 24 hours before surgery
History of motion sickness
Allergy to Propofol and Clonidine
Concomitant use of beta-blocker medication that may affect a patient's heart rate
Systolic blood pressure less than 100
History of using Steroid
History of myocardial infarction
History of tricyclic antidepressant use
History of kidney dysfunction

Study & Design

Study Type: interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Post-operative Nausea and Vomiting. Timepoint: Postoperative nausea and vomiting in recovery is recorded at 0-15-30 and 45 minutes. After transferring the patient to the surgical ward, the incidence of postoperative nausea and vomiting is evaluated at 6 and 24 hours. Method of measurement: Likert.

Secondary Outcome Measures

Name	Time	Method
Hemodynamic changes. Timepoint: Blood pressure and heart rate are recorded in the surgical ward in the operating room before induction after induction and in recovery at 0-15-30 and 45 minutes.After transferring the patient to the surgical ward, the patient's blood pressure is checked at 24,2,4,6,12 hours. Method of measurement: Monitoring.