Methods for Objective Selection of Competent Sperm
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Sponsor
- Enrollment
- 237
- Locations
- 1
- Primary Endpoint
- Gestation
Study Overview
Brief Summary
In spite of the achievements and developement of the assisted reproduction techniques in the last years, there is still an elevated percentage of unsuccessful treatments, needing sometimes repeated attempts to reach pregnancy.
The molecular physiology of sperm is being better characterized, and some reports have demonstrated the implication of different molecular processes in the pathophysiology of male infertility.
Recently, different sperm selection methods have been based on these molecular differences, showing a better quality of the sperm population after selection.
The main objective of this research project is to clinically apply these techniques in order to increase the pregnancy rates per cycle in infertile couples attending assisted reproduction treatments.
Study Design
- Study Type
- Interventional
- Allocation
- Randomized
- Intervention Model
- Parallel
- Primary Purpose
- Treatment
- Masking
- Triple (Participant, Care Provider, Outcomes Assessor)
Eligibility Criteria
- Ages
- 18 Years to 37 Years (Adult)
- Sex
- All
- Accepts Healthy Volunteers
- Yes
Inclusion Criteria
- •>3million sperm after swimming process
- •< 37 YEARS OLD
- •NO GYNECOLOGICAL ANOMOLIES
- •HORMONAL VALUES WITHIN CLINICAL RANGE
Exclusion Criteria
- Not provided
Arms & Interventions
Control
No sperm selection
Annexine V negative
Sperm selection with Annexine V protein
Intervention: Negative selection (Other)
Outcomes
Primary Outcomes
Gestation
Time Frame: 14 days
Sperm selection and blood sample confirming gestation
Secondary Outcomes
No secondary outcomes reported
Investigators
Marcos Meseguer
Embryologist IVI Valencia
Instituto Valenciano de Infertilidad, IVI VALENCIA