Metformin IN Asthma for Overweight and Obese Individuals (MINA)

Recruitment & Eligibility

Status: Not yet recruiting

Sex: All

Target Recruitment: Not specified

Inclusion Criteria

Inclusion Criteria: - Physician-diagnosed asthma on maintenance therapy - Not well-controlled asthma (ACT score <20, or at least one asthma exacerbation requiring corticosteroids in the prior 12 months) - Overweight or obesity: Body mass index =25kg/m2 - Adult: Age =18 Exclusion Criteria: - Currently pregnant, expect to become pregnant in the next 6 months or are currently breastfeeding - Major cardiovascular disease: heart failure, heart attack or stroke within the last 6 months - Other chronic lung disease, inclusive of chronic obstructive pulmonary disease, bronchiectasis, interstitial lung disease, pulmonary fibrosis - Active smoking or former smoker with =20 pack-year smoking history - Chronic kidney disease: estimated glomerular filtration rate =60 mL/min/1.73 m2 - Heavy alcohol use: in a typical week, 8 or more drinks for a woman or 15 or more drinks for a man - Liver disease: elevation in aspartate aminotransferase (AST) or alanine aminotransferase (ALT) > 2x the upper limit of normal or prior diagnosis of liver disease - Anemia: hemoglobin < 13 g/dl in males and hemoglobin < 11 g/dl in females - Taking Glucagon Like Peptide 1(GLP-1) medications for weight loss - Diabetes (Hemoglobin A1C = 6.5% or taking metformin or other medications used to treat diabetes) - Participation in any other clinical trial (observational studies are permitted)

Exclusion Criteria

Not provided

Study & Design

Study Type: Interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Number of completed telemedicine visits;Adherence to study drug;Retention rate

Secondary Outcome Measures

Name	Time	Method
Asthma control as assessed by the Asthma Control Test (ACT) score;Change in Asthma exacerbations rate;Pre-bronchodilator lung function;Fractional exhaled nitric oxide (FeNO);Airways hyperresponsiveness