Skeletal muscle characterization in frail elderly

Withdrawn

Conditions: veroudering
elderly with sarcopenia
frail elderly
vulnerability
10028302

Registration Number: NL-OMON36358

Lead Sponsor: Medisch Universitair Ziekenhuis Maastricht

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Withdrawn

Sex: Not specified

Target Recruitment: 50

Inclusion Criteria

frail male, non-obese (BMI <27 kg*m-2) subjects aged 70-90 years, with no history of participating in any regular exercise training program in the past 5 years, meeting 3 or more of these criteria: 1) unintentional weight loss of 10% or more since age of 60 2) self-reported low usual energy level (3 on a 0-10 scale), feeling unusually tired in the last month, or unusually weak in the last month; 3) low energy expenditure, defined as being in the lowest quintile of energy expenditure measured using a six-item version of the Minnesota Leisure Time Activity Questionnaire; 4) slowness, defined as being in the lowest quintile of walking speed over a 4,57-m distance; 5) weakness, defined as being in the lowest quintile of hand grip strength measured using a handheld dynamometer.
Subjects will be considered non-frail and, as such, eligible for inclusion in the study if 1 or less of the criteria is met (i.e. only non-frail individuals in healthy elderly control group).

Exclusion Criteria

Exclusion criteria are: type I and type II diabetes, the use of anticoagulation, female sex, senile dementia, participation in any regular exercise program.

Study & Design

Study Type: Observational invasive

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Primary study parameters are skeletal muscle fiber characteristics, : muscle<br /><br>fiber size and satellite cell content in type I and type II muscle fibers.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Secondary endpoints: blood amino acid profiles, blood glucose homeostasis,<br /><br>skeletal muscle function (hand-grip strenght), muscle strength (leg press),<br /><br>muscle mass and body composition (DEXA and CT). </p><br>