Paracetamol Metabolism in Post Operative Conditions
Completed
- Conditions
- Aortic Surgery and Treatment Post Operative With Paracetamol During 4 Days
- Registration Number
- NCT01152502
- Lead Sponsor
- University Hospital, Clermont-Ferrand
- Brief Summary
Follow-up of urinary concentration from paracetamol metabolites by patients with aortic surgery during 4 days therapeutic intake (perfalgan ® 4 x 1g IV/day)
- Detailed Description
D-15 to D0: selection
* patient information and non-opposition obtained
* inclusion and non inclusion criteria check
* clinical exam
D-1 to D0 : 24 hours diuresis
D0 : operation day
Before anesthesia :
* urine collection (paracetamol metabolites dosage)
* blood sampling (glutathion and liver function test)
Surgery:
* 1st paracetamol intake before closing
* Then administration every 6 hours
D1 to D4 :
* 24 hours urine collection (metabolites dosage)
* blood sampling et D1 and D4(glutathion and liver function test)
D5 : final clinical exam
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 30
Inclusion Criteria
- aortic surgery
- treatment with intraveinous paracetamol (4 grammes daily during 4 days)
- patient agrees to participate
Exclusion Criteria
-
- patient disagrees
- paracetamol contra-indication
- paracetamol intake 5 days before surgery
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Follow-up of urinary concentration from paracetamol metabolites by patients with aortic surgery during 4 days therapeutic intake (perfalgan ® 4 x 1g IV/day) during 4 days therapeutic intake
- Secondary Outcome Measures
Name Time Method - Follow-up of glutathion concentration during 4 post operative days during 4 post operative days Monitoring of liver function
Trial Locations
- Locations (1)
CHU Clermont-Ferrand
🇫🇷Clermont-Ferrand, France
CHU Clermont-Ferrand🇫🇷Clermont-Ferrand, France