NCT05494203Unknown不适用
Multi-omics Study and Drug Intervention Study of Spondyloarthritis
适应症
试验速览
- 阶段
- 不适用
- 入组人数
- 400
- 试验地点
- 1
- 主要终点
- Long-term outcomes after treatment
研究概览
简要总结
Spondyloarthritis (SpA) is a type of chronic inflammatory rheumatic disease that mainly affects the spine and peripheral joints, or joints, ligaments and tendons. This disease subtype has the same clinical and immunological features. Further explore the pathogenesis of spondyloarthritis, explore the guiding significance of different imaging examinations for spondyloarthritis, and study the efficacy and mechanism of different drugs for spondyloarthritis.
详细描述
- Clinical phenotype research. The clinical phenotype is the symptoms and signs of the disease and its evolution. Through the clinical phenotype research of spondyloarthritis, it is helpful to realize the diagnosis and grading of spondyloarthritis and help to achieve individualization Precise treatment.
- Transcriptomic research. The key genes and pathways involved in the pathogenesis of spondyloarthritis can be explored through transcriptomic research of spondyloarthritis, which can provide help for early diagnosis and seeking potential treatment methods.
- Microbiological research. Through the microbiome research on spondyloarthritis, the composition and function of intestinal flora in patients with spondyloarthritis can be deeply analyzed to provide help for diagnosis and treatment.
- Radiomics research. Through the radiomics research on spondyloarthritis, it is helpful to realize the diagnosis and grading of spondyloarthritis and the evaluation and prediction of treatment.
- Drug treatment research By studying the therapeutic effects of different drugs in patients with spondyloarthritis, it is helpful to explore the efficacy and mechanism of different drugs on spondyloarthritis, and to achieve precise and individualized treatment.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •The patient meets the revised AS New York diagnostic criteria or ASAS axial SpA classification criteria.
排除标准
- •patients with rheumatoid arthritis, scleroderma, systemic lupus erythematosus and other immune system diseases;
- •patients who had received head and neck radiotherapy;
- •patients with history of antidepressants and parasympathetic stimulants;
- •patients known to be infected with human immunodeficiency virus (HIV) or hepatitis C virus;
- •patients with sarcoidosis or tuberculosis infection.
- •patients with inflammatory bowel disease or uveitis.
结局指标
主要结局
Long-term outcomes after treatment
时间窗: 1 year
disease activity
次要结局
未报告次要终点
研究者
XiaobingWang
Clinical Professor, Principal Investigator
First Affiliated Hospital of Wenzhou Medical University
研究点 (1)
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