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临床试验/NCT00006360
NCT00006360已完成1 期

Conformal and Intensity Modulated Irradiation for Oropharyngeal Cancer

Radiation Therapy Oncology Group36 个研究点 分布在 2 个国家开始时间: 2001年2月最近更新:
适应症
相关药物

试验速览

阶段
1 期
状态
已完成
试验地点
36
主要终点
Acute salivary gland toxicity

研究概览

简要总结

RATIONALE: Radiation therapy uses high-energy x-rays to damage tumor cells.

PURPOSE: Phase I/II trial to study the effectiveness of radiation therapy in treating patients who have stage II or stage III oropharyngeal cancer.

详细描述

OBJECTIVES:

  • Assess target coverage and major salivary gland sparing in patients with stage II or III oropharyngeal cancer treated with intensity-modulated radiotherapy.
  • Determine the nature and prevalence of acute and late side effects of this treatment in these patients.
  • Determine the rate and pattern of locoregional tumor recurrence in these patients after this treatment.

OUTLINE: This is a multicenter study.

Patients receive 3-D conformal radiotherapy and/or intensity-modulated radiotherapy daily 5 days a week for 6 weeks, in an effort to spare major salivary glands.

Patients are followed every 3 months for 2 years, every 6 months for 3 years, and then annually thereafter.

研究设计

研究类型
Interventional
主要目的
Treatment

入排标准

年龄范围
18 Years 至 120 Years(Adult, Older Adult)
性别
All
接受健康志愿者

入选标准

  • 未提供

排除标准

  • 未提供

结局指标

主要结局

Acute salivary gland toxicity

Acute mucositis and other acute and late toxicities

Locoregional control

Whole mouth saliva output relative to pre-radiotherapy measurements

次要结局

未报告次要终点

研究者

申办方类型
Network
责任方
Sponsor

研究点 (36)

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