Evaluation of the Effects of a Novel Dietary Microalgae Based Ingredient on Muscle Recovery and Endurance Capacity

Not Applicable

Completed

• Conditions: Healthy

• Registration Number: NCT05760742
• Lead Sponsor: Microphyt

Brief Summary

The purpose of this investigation is to examine the effects of consuming a new dietary microalgae based supplement vs. placebo on neuromuscular function, energy utilization, soreness, perceptual wellness, swelling, and markers of muscle damage and inflammation in healthy young men before and after an acute exercise-induced muscle damage protocol (downhill running), and influence on endurance capacity after prolonged consumption.

Detailed Description

Not available

Study Timeline

• Study Start: 2023-01-10
• Study First Submitted: 2023-02-23
• Study First Submitted QC: 2023-03-06
• Study First Posted: 2023-03-08
• Primary Completion: 2023-08-01
• Study Completion: 2023-08-18
• Status Verified: 2023-09
• Last Update Submitted: 2023-09-21
• Last Update Posted: 2023-09-22

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Male
• Target Recruitment: 80

Inclusion Criteria

• Male participants
• Healthy as assessed by Medical and activity history questionnaire (MHQ)
• Recreationally active according to American College of Sports Medicine guidelines
• Able to provide written and dated informed consent to participate in the study

Exclusion Criteria

• Untrained
• Any response of "yes" on the PAR-Q+
• Physical limitations preventing running, countermovement jump, and strength (peak isometric torque and peak isokinetic torque) assessments

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Primary Outcome Measures

Name	Time	Method
Neuromuscular function	From 0 to week 4	isokinetic peak torque in Newton per meter (N/m)

Secondary Outcome Measures

Name	Time	Method
Isometric neuromuscular function	From 0 to week 8	peak torque in Newton per meter (N/m)
Endurance capacity	From 0 to week 8	Maximal oxygen consumption (VO2max) determined during graded exercise test
Swelling - Muscle thickness (mm or cm)	From 0 to week 4	Evaluated using musculoskeletal ultrasound
Tumor necrosis factor-α (ug/ml)	After 4 weeks of supplementation	Blood marker analyzis - inflammation
Swelling - overall thigh circumference (mm or cm)	From 0 to week 4	Evaluated using musculoskeletal ultrasound
Myoglobin (ug/l)	After 4 weeks of supplementation	Blood marker analyzis
Interleukin-6 (pg/ml)	After 4 weeks of supplementation	Blood marker analyzis - inflammation
Creatine kinase (UI/I)	After 4 weeks of supplementation	Blood marker analyzis
C-reactive protein (mg/l)	After 4 weeks of supplementation	Blood marker analyzis - inflammation
Isometric Neuromuscular function	From 0 to week 4	Peak torque in Newton per meter (N/m)
Energy utilization (Oxygen consumption - VO2)	From 0 to week 8	Running economy during a 5-minute run at 80% of the speed at VO2max with gaz exchange analyzis
Isokinetic neuromuscular function	From 0 to week 8	peak torque in Newton per meter (N/m)
Soreness and perceptual wellness	From 0 to week 8	Evaluated using using a 100-point numerical pain rating scale anchored with 0= no pain to 100= the most intense pain sensation imaginable after exercise-induced muscle damage protocol
lactate dehydrogenase (U/L)	After 4 weeks of supplementation	Blood marker analyzis

Trial Locations

Locations (1)

University of Central Florida; 🇺🇸 Orlando, Florida, United States