Evaluation of the Protective Effects of a Novel Dietary Microalgae Supplement (PeLiv) Following Exercise-induced Muscle Damage and Influence on Endurance Capacity After Prolonged Consumption
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Sponsor
- Microphyt
- Enrollment
- 80
- Locations
- 1
- Primary Endpoint
- Neuromuscular function
Study Overview
Brief Summary
The purpose of this investigation is to examine the effects of consuming a new dietary microalgae based supplement vs. placebo on neuromuscular function, energy utilization, soreness, perceptual wellness, swelling, and markers of muscle damage and inflammation in healthy young men before and after an acute exercise-induced muscle damage protocol (downhill running), and influence on endurance capacity after prolonged consumption.
Study Design
- Study Type
- Interventional
- Allocation
- Randomized
- Intervention Model
- Parallel
- Primary Purpose
- Prevention
- Masking
- Triple (Participant, Care Provider, Investigator)
Eligibility Criteria
- Ages
- 18 Years to 35 Years (Adult)
- Sex
- Male
- Accepts Healthy Volunteers
- Yes
Inclusion Criteria
- •Male participants
- •Healthy as assessed by Medical and activity history questionnaire (MHQ)
- •Recreationally active according to American College of Sports Medicine guidelines
- •Able to provide written and dated informed consent to participate in the study
Exclusion Criteria
- •Untrained
- •Any response of "yes" on the PAR-Q+
- •Physical limitations preventing running, countermovement jump, and strength (peak isometric torque and peak isokinetic torque) assessments
Arms & Interventions
Placebo group
2 capsules of Maltodextrin per day
Intervention: Placebo (Dietary Supplement)
MicAlgae100
2 capsules per day containing 100mg of microalgae based ingredient
Intervention: MicAlgae (Dietary Supplement)
MicAlgae250
2 capsules per day containing 250mg of microalgae based ingredient
Intervention: MicAlgae (Dietary Supplement)
MicAlgae500
2 capsules per day containing 500mg of microalgae based ingredient
Intervention: MicAlgae (Dietary Supplement)
Outcomes
Primary Outcomes
Neuromuscular function
Time Frame: From 0 to week 4
isokinetic peak torque in Newton per meter (N/m)
Secondary Outcomes
- Energy utilization (Oxygen consumption - VO2)(From 0 to week 8)
- Isometric neuromuscular function(From 0 to week 8)
- Endurance capacity(From 0 to week 8)
- Swelling - Muscle thickness (mm or cm)(From 0 to week 4)
- Tumor necrosis factor-α (ug/ml)(After 4 weeks of supplementation)
- Swelling - overall thigh circumference (mm or cm)(From 0 to week 4)
- Myoglobin (ug/l)(After 4 weeks of supplementation)
- Interleukin-6 (pg/ml)(After 4 weeks of supplementation)
- Creatine kinase (UI/I)(After 4 weeks of supplementation)
- C-reactive protein (mg/l)(After 4 weeks of supplementation)
- Isometric Neuromuscular function(From 0 to week 4)
- Isokinetic neuromuscular function(From 0 to week 8)
- Soreness and perceptual wellness(From 0 to week 8)
- lactate dehydrogenase (U/L)(After 4 weeks of supplementation)
- Energy utilization (Oxygen consumption - VO2)(From 0 to week 4)
- Endurance capacity(From 0 to week 4)
- Soreness and perceptual wellness(From 0 to week 4)