Impact of Attention Deficit/Hyperactivity Disorder on the Post-detoxification Alcohol Relapse Rate
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Sponsor
- Enrollment
- 113
- Locations
- 2
- Primary Endpoint
- Cumulated rate of alcohol relapse
Study Overview
Brief Summary
Some recent studies have found that adult attention deficit - hyperactivity disorder (ADHD) was frequent among patients with alcohol-dependence. However, no investigation has ever addressed whether ADHD may impact the drinking outcome.
Moreover, most of the different aforementioned studies assessed ADHD using the ADHD self-report scale (ASRS). The ASRS is a screening questionnaire that is of limited diagnostic value, and the overrepresentation of high-score ASRS among patients with alcohol-dependence could be in part due to differential diagnoses such as antisocial or borderline personality disorders, executive function impairments, or isolated impulsiveness.
The study aims to evaluate "ADHD: Gaps between patients with Alcohol Dependence and Impact on early Relapse" (AGADIR). In AGADIR, subjects with alcohol-dependence are recruited at the end of a residential detoxification program. They are assessed for ADHD using the ASRS, but also with a standardized diagnostic tool, i.e., the Diagnostic Interview for ADHD in adults (DIVA 2.0). Potential differential diagnoses are screened during the baseline visit. The patients are followed-up during the 12 first post-detox weeks, through a standardized psychosocial treatment. ASRS is re-performed at the end of the follow-up.
Study Design
- Study Type
- Observational
- Observational Model
- Cohort
- Time Perspective
- Prospective
Eligibility Criteria
- Ages
- 18 Years to — (Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •current DSM-IV-Tr criteria for alcohol-dependence
- •current residential alcohol detoxification program
- •Non-inclusion Criteria:
- •concurrent alcohol withdrawal symptoms, i.e., CIWA-Ar ≥ 10
- •benzodiazepine diazepam-equivalent dose > 30 mg
- •medical history of neurological impairment (excluding alcohol-induced cognitive disorders)
- •guardianship or loss of liberty
- •pregnant or lactating woman
Exclusion Criteria
- Not provided
Outcomes
Primary Outcomes
Cumulated rate of alcohol relapse
Time Frame: 12 weeks
Cumulated rate of alcohol relapse during the 12 weeks following the detoxification program
Secondary Outcomes
- Psychometric properties of the ASRS(12 weeks)
- Multivariate analysis of the alcohol relapse(12 weeks)